Int. J. Mol. Sci. 2012, 13(4), 5125-5137; doi:10.3390/ijms13045125
Article

A DNA Network as an Information Processing System

Received: 29 February 2012; in revised form: 31 March 2012 / Accepted: 17 April 2012 / Published: 23 April 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Biomolecular systems that can process information are sought for computational applications, because of their potential for parallelism and miniaturization and because their biocompatibility also makes them suitable for future biomedical applications. DNA has been used to design machines, motors, finite automata, logic gates, reaction networks and logic programs, amongst many other structures and dynamic behaviours. Here we design and program a synthetic DNA network to implement computational paradigms abstracted from cellular regulatory networks. These show information processing properties that are desirable in artificial, engineered molecular systems, including robustness of the output in relation to different sources of variation. We show the results of numerical simulations of the dynamic behaviour of the network and preliminary experimental analysis of its main components.
Keywords: biological networks; information processing; DNA
PDF Full-text Download PDF Full-Text [691 KB, uploaded 19 June 2014 04:15 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Santini, C.C.; Bath, J.; Turberfield, A.J.; Tyrrell, A.M. A DNA Network as an Information Processing System. Int. J. Mol. Sci. 2012, 13, 5125-5137.

AMA Style

Santini CC, Bath J, Turberfield AJ, Tyrrell AM. A DNA Network as an Information Processing System. International Journal of Molecular Sciences. 2012; 13(4):5125-5137.

Chicago/Turabian Style

Santini, Cristina Costa; Bath, Jonathan; Turberfield, Andrew J.; Tyrrell, Andy M. 2012. "A DNA Network as an Information Processing System." Int. J. Mol. Sci. 13, no. 4: 5125-5137.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert