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Int. J. Mol. Sci. 2012, 13(4), 5125-5137; doi:10.3390/ijms13045125

A DNA Network as an Information Processing System

1 Department of Electronics, University of York, York YO10 5DD, UK 2 Clarendon Laboratory, Department of Physics, University of Oxford, Parks Road, Oxford OX1 3PU, UK Current address: College of Computer and Information Sciences, King Saud University, P.O.Box 22452, Riyadh 11495, KSA.
* Author to whom correspondence should be addressed.
Received: 29 February 2012 / Revised: 31 March 2012 / Accepted: 17 April 2012 / Published: 23 April 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Biomolecular systems that can process information are sought for computational applications, because of their potential for parallelism and miniaturization and because their biocompatibility also makes them suitable for future biomedical applications. DNA has been used to design machines, motors, finite automata, logic gates, reaction networks and logic programs, amongst many other structures and dynamic behaviours. Here we design and program a synthetic DNA network to implement computational paradigms abstracted from cellular regulatory networks. These show information processing properties that are desirable in artificial, engineered molecular systems, including robustness of the output in relation to different sources of variation. We show the results of numerical simulations of the dynamic behaviour of the network and preliminary experimental analysis of its main components.
Keywords: biological networks; information processing; DNA biological networks; information processing; DNA
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Santini, C.C.; Bath, J.; Turberfield, A.J.; Tyrrell, A.M. A DNA Network as an Information Processing System. Int. J. Mol. Sci. 2012, 13, 5125-5137.

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