Int. J. Mol. Sci. 2012, 13(4), 4696-4703; doi:10.3390/ijms13044696
Article

Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid

Zhenting Du 1,2,* email, Changmei Si 1 email, Youqiang Li 1 email, Yin Wang 1 email and Jing Lu 1 email
1 College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China 2 Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Talimu University, Alaer, Xinjiang 843300, China
* Author to whom correspondence should be addressed.
Received: 20 February 2012; in revised form: 19 March 2012 / Accepted: 30 March 2012 / Published: 12 April 2012
(This article belongs to the Section Green Chemistry)
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Abstract: A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%–95% yield.
Keywords: silica sulfuric acid; 5-substituted 1H-tetrazoles; [3+2] cycloaddition

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MDPI and ACS Style

Du, Z.; Si, C.; Li, Y.; Wang, Y.; Lu, J. Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid. Int. J. Mol. Sci. 2012, 13, 4696-4703.

AMA Style

Du Z, Si C, Li Y, Wang Y, Lu J. Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid. International Journal of Molecular Sciences. 2012; 13(4):4696-4703.

Chicago/Turabian Style

Du, Zhenting; Si, Changmei; Li, Youqiang; Wang, Yin; Lu, Jing. 2012. "Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid." Int. J. Mol. Sci. 13, no. 4: 4696-4703.

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