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Int. J. Mol. Sci. 2012, 13(4), 4696-4703; doi:10.3390/ijms13044696
Article

Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid

1,2,* , 1
, 1
, 1
 and 1
1 College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China 2 Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Talimu University, Alaer, Xinjiang 843300, China
* Author to whom correspondence should be addressed.
Received: 20 February 2012 / Revised: 19 March 2012 / Accepted: 30 March 2012 / Published: 12 April 2012
(This article belongs to the Section Green Chemistry)

Abstract

A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%–95% yield.
Keywords: silica sulfuric acid; 5-substituted 1H-tetrazoles; [3+2] cycloaddition silica sulfuric acid; 5-substituted 1H-tetrazoles; [3+2] cycloaddition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Du, Z.; Si, C.; Li, Y.; Wang, Y.; Lu, J. Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid. Int. J. Mol. Sci. 2012, 13, 4696-4703.

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