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Int. J. Mol. Sci. 2012, 13(3), 3738-3750; doi:10.3390/ijms13033738
Article

Antihyperglycemic and Antioxidative Effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in Mice Fed with a High Fat Diet

1
, 1
, 2
 and 1,*
Received: 2 November 2011; in revised form: 2 March 2012 / Accepted: 16 March 2012 / Published: 21 March 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: The effect of dietary feeding of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) on the glucose metabolism and antioxidative status in mice under high fat diet conditions was investigated. The mice were randomly divided and given experimental diets for six weeks: normal control (NC group), high fat (HF group), and high fat supplemented with either HEMC (HF+HEMC group) or HPMC (HF+HPMC group). At the end of the experimental period, the HF group exhibited markedly higher blood glucose and insulin levels as well as a higher erythrocyte lipid peroxidation rate relative to the control group. However, diet supplementation of HEMC and HPMC was found to counteract the high fat-induced hyperglycemia and oxidative stress via regulation of antioxidant and hepatic glucose-regulating enzyme activities. These findings illustrate that HEMC and HPMC were similarly effective in improving the glucose metabolism and antioxidant defense system in high fat-fed mice and they may be beneficial as functional biomaterials in the development of therapeutic agents against high fat diet-induced hyperglycemia and oxidative stress.
Keywords: hydroxyethyl methylcellulose; hydroxypropyl methylcellulose; glucose metabolism; antioxidative effect; high fat diet hydroxyethyl methylcellulose; hydroxypropyl methylcellulose; glucose metabolism; antioxidative effect; high fat diet
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ban, S.J.; Rico, C.W.; Um, I.C.; Kang, M.Y. Antihyperglycemic and Antioxidative Effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in Mice Fed with a High Fat Diet. Int. J. Mol. Sci. 2012, 13, 3738-3750.

AMA Style

Ban SJ, Rico CW, Um IC, Kang MY. Antihyperglycemic and Antioxidative Effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in Mice Fed with a High Fat Diet. International Journal of Molecular Sciences. 2012; 13(3):3738-3750.

Chicago/Turabian Style

Ban, Su Jeong; Rico, Catherine W.; Um, In Chul; Kang, Mi Young. 2012. "Antihyperglycemic and Antioxidative Effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in Mice Fed with a High Fat Diet." Int. J. Mol. Sci. 13, no. 3: 3738-3750.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert