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Tannins, Peptic Ulcers and Related Mechanisms
Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil
* Author to whom correspondence should be addressed.
Received: 29 January 2012; in revised form: 26 February 2012 / Accepted: 28 February 2012 / Published: 8 March 2012
Abstract: This review of the current literature aims to study correlations between the chemical structure and gastric anti-ulcer activity of tannins. Tannins are used in medicine primarily because of their astringent properties. These properties are due to the fact that tannins react with the tissue proteins with which they come into contact. In gastric ulcers, this tannin-protein complex layer protects the stomach by promoting greater resistance to chemical and mechanical injury or irritation. Moreover, in several experimental models of gastric ulcer, tannins have been shown to present antioxidant activity, promote tissue repair, exhibit anti Helicobacter pylori effects, and they are involved in gastrointestinal tract anti-inflammatory processes. The presence of tannins explains the anti-ulcer effects of many natural products.
Keywords: tannins; antiulcer activity; gastric ulcer; natural products; Helicobacter pylori
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de Jesus, N.Z.T.; Falcão, H.S.; Gomes, I.F.; Leite, T.J.A.; Lima, G.R.M.; Barbosa-Filho, J.M.; Tavares, J.F.; Silva, M.S.; Athayde-Filho, P.F.; Batista, L.M. Tannins, Peptic Ulcers and Related Mechanisms. Int. J. Mol. Sci. 2012, 13, 3203-3228.
de Jesus NZT, Falcão HS, Gomes IF, Leite TJA, Lima GRM, Barbosa-Filho JM, Tavares JF, Silva MS, Athayde-Filho PF, Batista LM. Tannins, Peptic Ulcers and Related Mechanisms. International Journal of Molecular Sciences. 2012; 13(3):3203-3228.
de Jesus, Neyres Zinia Taveira; Falcão, Heloina de Souza; Gomes, Isis Fernandes; Leite, Thiago Jose de Almeida; Lima, Gedson Rodrigues de Morais; Barbosa-Filho, Jose Maria; Tavares, Josean Fechine; Silva, Marcelo Sobral da; Athayde-Filho, Petrônio Filgueiras de; Batista, Leonia Maria. 2012. "Tannins, Peptic Ulcers and Related Mechanisms." Int. J. Mol. Sci. 13, no. 3: 3203-3228.