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Int. J. Mol. Sci. 2012, 13(3), 3203-3228; doi:10.3390/ijms13033203

Tannins, Peptic Ulcers and Related Mechanisms

Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil
Author to whom correspondence should be addressed.
Received: 29 January 2012 / Revised: 26 February 2012 / Accepted: 28 February 2012 / Published: 8 March 2012


This review of the current literature aims to study correlations between the chemical structure and gastric anti-ulcer activity of tannins. Tannins are used in medicine primarily because of their astringent properties. These properties are due to the fact that tannins react with the tissue proteins with which they come into contact. In gastric ulcers, this tannin-protein complex layer protects the stomach by promoting greater resistance to chemical and mechanical injury or irritation. Moreover, in several experimental models of gastric ulcer, tannins have been shown to present antioxidant activity, promote tissue repair, exhibit anti Helicobacter pylori effects, and they are involved in gastrointestinal tract anti-inflammatory processes. The presence of tannins explains the anti-ulcer effects of many natural products.
Keywords: tannins; antiulcer activity; gastric ulcer; natural products; Helicobacter pylori tannins; antiulcer activity; gastric ulcer; natural products; Helicobacter pylori
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

de Jesus, N.Z.T.; Falcão, H.S.; Gomes, I.F.; Leite, T.J.A.; Lima, G.R.M.; Barbosa-Filho, J.M.; Tavares, J.F.; Silva, M.S.; Athayde-Filho, P.F.; Batista, L.M. Tannins, Peptic Ulcers and Related Mechanisms. Int. J. Mol. Sci. 2012, 13, 3203-3228.

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