Int. J. Mol. Sci. 2012, 13(2), 2219-2238; doi:10.3390/ijms13022219
Review

Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology

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Received: 16 January 2012; in revised form: 26 January 2012 / Accepted: 14 February 2012 / Published: 17 February 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Alpha7 nicotinic acetylcholine receptor (α7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of α7 nAChR are a wide group represented by conotoxin and bungarotoxin. Even Alzheimer’s disease drug memantine acting as an antagonist in its side pathway belongs in this group. Agonists of α7 nAChR are suitable for treatment of multiple cognitive dysfunctions such as Alzheimer’s disease or schizophrenia. Inflammation or even sepsis can be ameliorated by the agonistic acting compounds. Preparations RG3487, SEN34625/WYE-103914, SEN12333, ABT-107, Clozapine, GTS-21, CNI-1493, and AR-R17779 are representative examples of the novel compounds with affinity toward the α7 nAChR. Pharmacological, toxicological, and medicinal significance of α7 nAChR are discussed throughout this paper.
Keywords: inflammation; cholinergic anti-inflammatory pathway; schizophrenia; Alzheimer’s disease; cognitive disorder; agonist; antagonist
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MDPI and ACS Style

Pohanka, M. Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology. Int. J. Mol. Sci. 2012, 13, 2219-2238.

AMA Style

Pohanka M. Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology. International Journal of Molecular Sciences. 2012; 13(2):2219-2238.

Chicago/Turabian Style

Pohanka, Miroslav. 2012. "Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology." Int. J. Mol. Sci. 13, no. 2: 2219-2238.

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