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Antioxidant-Induced Stress
Int. J. Mol. Sci. 2012, 13(2), 2110-2118; doi:10.3390/ijms13022110
Article

The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis

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Received: 6 January 2012 / Revised: 6 February 2012 / Accepted: 10 February 2012 / Published: 16 February 2012
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Abstract

In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU.
Keywords: Toll-like receptor 4; Cytokine; cytometric bead array technology; aqueous humor; Anterior Uveitis Toll-like receptor 4; Cytokine; cytometric bead array technology; aqueous humor; Anterior Uveitis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, J.; Lu, H.; Xu, Y.; Hu, X.; Chen, W.; Li, S. The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis. Int. J. Mol. Sci. 2012, 13, 2110-2118.

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