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Int. J. Mol. Sci. 2012, 13(2), 2110-2118; doi:10.3390/ijms13022110

The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis

1
Department of Ophthalmology, Chaoyang Hospital ,Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China
2
Department of Ophthalmology, Haidian Maternal and Child Health Hospital, Tongji Medical University, Beijing 100080, China
*
Author to whom correspondence should be addressed.
Received: 6 January 2012 / Revised: 6 February 2012 / Accepted: 10 February 2012 / Published: 16 February 2012
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Abstract

In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU.
Keywords: Toll-like receptor 4; Cytokine; cytometric bead array technology; aqueous humor; Anterior Uveitis Toll-like receptor 4; Cytokine; cytometric bead array technology; aqueous humor; Anterior Uveitis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wang, J.; Lu, H.; Xu, Y.; Hu, X.; Chen, W.; Li, S. The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis. Int. J. Mol. Sci. 2012, 13, 2110-2118.

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