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• Zhang, Q
• Wu, Y
• Sha, H
• Zhang, P
• Jia, J
• Hu, Y
• Zhu, J
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• Zhang, Q
• Wu, Y
• Sha, H
• Zhang, P
• Jia, J
• Hu, Y
• Zhu, J
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• Wu, Y
• Sha, H
• Zhang, P
• Jia, J
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• Zhu, J

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Int. J. Mol. Sci. 2012, 13(2), 1670-1679; doi:10.3390/ijms13021670

Article

Early Exercise Affects Mitochondrial Transcription Factors Expression after Cerebral Ischemia in Rats

Qi Zhang ^1,2, Yi Wu ^1,2,3,* , Hongying Sha ⁴, Pengyue Zhang ^1,2, Jie Jia ^1,2, Yongshan Hu ^1,2,3 and Jianhong Zhu ^4,5

¹ Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai 200040, China ² Department of Sports Medicine and Rehabilitation, Medical College of Fudan University, Shanghai 200032, China ³ The Yonghe Branch of Huashan Hospital, Fudan University, Shanghai 200436, China ⁴ State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China ⁵ Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China

* Author to whom correspondence should be addressed.

Received: 20 December 2011; in revised form: 20 January 2012 / Accepted: 29 January 2012 / Published: 6 February 2012

Download PDF Full-Text [187 KB, Updated Version, uploaded 8 February 2012 11:21 CET]

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Abstract: Increasing evidence shows that exercise training is neuroprotective after stroke, but the underlying mechanisms are unknown. To clarify this critical issue, the current study investigated the effects of early treadmill exercise on the expression of mitochondrial biogenesis factors. Adult rats were subjected to ischemia induced by middle cerebral artery occlusion followed by reperfusion. Expression of two genes critical for transcriptional regulation of mitochondrial biogenesis, peroxisome proliferator-activated receptor coactivator-1 (PGC-1) and nuclear respiratory factor-1 (NRF-1), were examined by RT-PCR after five days of exercise starting at 24 h after ischemia. Mitochondrial protein cytochrome C oxidase subunit IV (COX IV) was detected by Western blot. Neurological status and cerebral infarct volume were evaluated as indices of brain damage. Treadmill training increased levels of PGC-1 and NRF-1 mRNA, indicating that exercise promotes rehabilitation after ischemia via regulation of mitochondrial biogenesis.

Keywords: exercise; ischemia; PGC-1; NRF-1; COX IV; neuroprotection

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