Int. J. Mol. Sci. 2012, 13(10), 13713-13725; doi:10.3390/ijms131013713

The Role of Neurotrophins in Multiple Sclerosis—Pathological and Clinical Implications

1,2,* email and 3,4email
Received: 14 August 2012; in revised form: 28 September 2012 / Accepted: 10 October 2012 / Published: 22 October 2012
(This article belongs to the Special Issue Recent Advances in the Research of Multiple Sclerosis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS) with unknown etiology. It was recently suggested that autoimmunity, which had long been considered to be destructive in MS, might also play a protective role in the CNS of MS patients. Neurotrophins are polypeptides belonging to the neurotrophic factor family. While neurotrophins mediate cell survival and proliferation in the nervous system, they are also expressed within peripheral blood mononuclear cells fraction (PBMCs) of immunological system. In MS additional neurotrophic support from PBMCs might compensate relative neurotrophins deficiency in the damaged CNS tissue that needs to be repaired. Failure to produce the adequate neurotrophins concentrations might result in decreased protection of the CNS, consequently leading to increased atrophy, which is the main determinant of MS patients’ end-point disability. There are several lines of evidence, both from clinical research and animal models, suggesting that neurotrophins play a pivotal role in neuroprotective and neuroregenerative processes that are often defective in the course of MS. It seems that neuroprotective strategies might be used as potentially valuable add-on therapies, alongside traditional immunomodulatory treatment in multiple sclerosis.
Keywords: multiple sclerosis; neurotrophins; neuroimmunology; peripheral blood mononuclear cells; neuroprotective autoimmunity
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MDPI and ACS Style

Kalinowska-Lyszczarz, A.; Losy, J. The Role of Neurotrophins in Multiple Sclerosis—Pathological and Clinical Implications. Int. J. Mol. Sci. 2012, 13, 13713-13725.

AMA Style

Kalinowska-Lyszczarz A, Losy J. The Role of Neurotrophins in Multiple Sclerosis—Pathological and Clinical Implications. International Journal of Molecular Sciences. 2012; 13(10):13713-13725.

Chicago/Turabian Style

Kalinowska-Lyszczarz, Alicja; Losy, Jacek. 2012. "The Role of Neurotrophins in Multiple Sclerosis—Pathological and Clinical Implications." Int. J. Mol. Sci. 13, no. 10: 13713-13725.

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