Next Article in Journal
The Behavior of Matrix Metalloproteinases and Their Inhibitors in Colorectal Cancer
Next Article in Special Issue
Effect of High-Dose Vitamin D3 Intake on Ambulation, Muscular Pain and Bone Mineral Density in a Woman with Multiple Sclerosis: A 10-Year Longitudinal Case Report
Previous Article in Journal
Lower Temperature Cultures Enlarge the Effects of Vitreoscilla Hemoglobin Expression on Recombinant Pichia pastoris
Previous Article in Special Issue
Molecular Pathogenesis of Neuromyelitis Optica
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2012, 13(10), 13227-13239; doi:10.3390/ijms131013227

MicroRNAs as Active Players in the Pathogenesis of Multiple Sclerosis

Department of Pathophysiology and transplantation, “Dino Ferrari” Center, University of Milan, IRCCS Foundation Cà Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy
*
Author to whom correspondence should be addressed.
Received: 13 August 2012 / Revised: 27 September 2012 / Accepted: 8 October 2012 / Published: 15 October 2012
(This article belongs to the Special Issue Recent Advances in the Research of Multiple Sclerosis)
View Full-Text   |   Download PDF [253 KB, 19 June 2014; original version 19 June 2014]   |  

Abstract

MicroRNAs (miRNAs) are a recently discovered group of small noncoding RNAs that regulate gene expression post-transcriptionally. They are highly expressed in cells of the immune system, as well as in the central nervous system, and they are deregulated in various neurological disorders. Emerging evidence underlines an involvement of miRNAs in the pathogenesis of Multiple Sclerosis (MS). A number of miRNAs have been found to be dysregulated in blood cells from MS patients, in brain lesions, as well as in biological fluids such as serum and plasma. Despite miRNA altered expression likely showing a high tissue specificity, some profile similarities could be observed for certain miRNAs such as miR-326—such as upregulation in both active lesions and blood—though not for others such as miR-323, which demonstrated upregulation in whole blood, active brain lesions, and T-reg cells, but not in the serum of MS patients. In this review, the possible role of miRNAs in MS pathogenesis will be discussed according to all the available literature, with a particular emphasis on the possibility of considering extracellular miRNAs as a new source for both biomarker identification and therapeutic target discovery. View Full-Text
Keywords: multiple sclerosis; microRNA; immune system; biomarker; central nervous system multiple sclerosis; microRNA; immune system; biomarker; central nervous system
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Fenoglio, C.; Ridolfi, E.; Galimberti, D.; Scarpini, E. MicroRNAs as Active Players in the Pathogenesis of Multiple Sclerosis. Int. J. Mol. Sci. 2012, 13, 13227-13239.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top