Int. J. Mol. Sci. 2012, 13(1), 840-865; doi:10.3390/ijms13010840
Article

MiRNAs and LincRNAs: Could They Be Considered as Biomarkers in Colorectal Cancer?

1,2,* email, 1email, 3email and 1,4email
Received: 2 November 2011; in revised form: 15 December 2011 / Accepted: 28 December 2011 / Published: 16 January 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Recent advances in the field of RNA research have provided compelling evidence implicating microRNA (miRNA) and long non-coding RNA molecules in many diverse and substantial biological processes, including transcriptional and post-transcriptional regulation of gene expression, genomic imprinting, and modulation of protein activity. Thus, studies of non-coding RNA (ncRNA) may contribute to the discovery of possible biomarkers in human cancers. Considering that the response to chemotherapy can differ amongst individuals, researchers have begun to isolate and identify the genes responsible. Identification of targets of this ncRNA associated with cancer can suggest that networks of these linked to oncogenes or tumor suppressors play pivotal roles in cancer development. Moreover, these ncRNA are attractive drug targets since they may be differentially expressed in malignant versus normal cells and regulate expression of critical proteins in the cell. This review focuses on ncRNAs that are differently expressed in malignant tissue, and discusses some of challenges derived from their use as potential biomarkers of tumor properties.
Keywords: biomarkers; cancer; prognostic; non-coding RNA
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MDPI and ACS Style

Zarate, R.; Boni, V.; Bandres, E.; Garcia-Foncillas, J. MiRNAs and LincRNAs: Could They Be Considered as Biomarkers in Colorectal Cancer? Int. J. Mol. Sci. 2012, 13, 840-865.

AMA Style

Zarate R, Boni V, Bandres E, Garcia-Foncillas J. MiRNAs and LincRNAs: Could They Be Considered as Biomarkers in Colorectal Cancer? International Journal of Molecular Sciences. 2012; 13(1):840-865.

Chicago/Turabian Style

Zarate, Ruth; Boni, Valentina; Bandres, Eva; Garcia-Foncillas, Jesús. 2012. "MiRNAs and LincRNAs: Could They Be Considered as Biomarkers in Colorectal Cancer?" Int. J. Mol. Sci. 13, no. 1: 840-865.

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