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Int. J. Mol. Sci. 2011, 12(9), 5747-5761; doi:10.3390/ijms12095747

The Antioxidant Activity of New Coumarin Derivatives

1,2,* , 1
1 Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia 2 Biotechnology Division, Applied Science Department, University of Technology, Baghdad 10066, Iraq
* Author to whom correspondence should be addressed.
Received: 12 July 2011 / Revised: 18 August 2011 / Accepted: 22 August 2011 / Published: 7 September 2011
(This article belongs to the Special Issue Antioxidants)
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The antioxidant activity of two synthesized coumarins namely, N-(4,7-dioxo-2-phenyl-1,3-oxazepin-3(2H,4H,7H)-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 5 and N-(4-oxo-2-phenylthiazolidin-3-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 6 were studied with the DPPH, hydrogen peroxide and nitric oxide radical methods and compared with the known antioxidant ascorbic acid. Compounds 5 and 6 were synthesized in a good yield from the addition reaction of maleic anhydride or mercaptoacetic acid to compound 4, namely N'-benzylidene-2-(2-oxo-2H-chromen-4-yloxy)acetohydrazide. Compound 4 was synthesized by the condensation of compound 3, namely 2-(2-oxo-2H-chromen-4-yloxy) acetohydrazide, with benzaldehyde. Compound 3, however, was synthesized from the addition of hydrazine to compound 2, namely ethyl 2-(2-oxo-2H-chromen-4-yloxy)acetate, which was synthesized from the reaction of ethyl bromoacetate with 4-hydroxycoumarin 1. Structures for the synthesized coumarins 26 are proposed on the basis of spectroscopic evidence.
Keywords: antioxidant; ethyl bromoacetate; 4-hydroxycoumarin; maleic anhydride antioxidant; ethyl bromoacetate; 4-hydroxycoumarin; maleic anhydride
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kadhum, A.A.H.; Al-Amiery, A.A.; Musa, A.Y.; Mohamad, A.B. The Antioxidant Activity of New Coumarin Derivatives. Int. J. Mol. Sci. 2011, 12, 5747-5761.

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