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Int. J. Mol. Sci. 2011, 12(9), 5747-5761; doi:10.3390/ijms12095747
Article

The Antioxidant Activity of New Coumarin Derivatives

1
, 1,2,* , 1
 and 1
Received: 12 July 2011; in revised form: 18 August 2011 / Accepted: 22 August 2011 / Published: 7 September 2011
(This article belongs to the Special Issue Antioxidants)
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Abstract: The antioxidant activity of two synthesized coumarins namely, N-(4,7-dioxo-2-phenyl-1,3-oxazepin-3(2H,4H,7H)-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 5 and N-(4-oxo-2-phenylthiazolidin-3-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 6 were studied with the DPPH, hydrogen peroxide and nitric oxide radical methods and compared with the known antioxidant ascorbic acid. Compounds 5 and 6 were synthesized in a good yield from the addition reaction of maleic anhydride or mercaptoacetic acid to compound 4, namely N'-benzylidene-2-(2-oxo-2H-chromen-4-yloxy)acetohydrazide. Compound 4 was synthesized by the condensation of compound 3, namely 2-(2-oxo-2H-chromen-4-yloxy) acetohydrazide, with benzaldehyde. Compound 3, however, was synthesized from the addition of hydrazine to compound 2, namely ethyl 2-(2-oxo-2H-chromen-4-yloxy)acetate, which was synthesized from the reaction of ethyl bromoacetate with 4-hydroxycoumarin 1. Structures for the synthesized coumarins 26 are proposed on the basis of spectroscopic evidence.
Keywords: antioxidant; ethyl bromoacetate; 4-hydroxycoumarin; maleic anhydride antioxidant; ethyl bromoacetate; 4-hydroxycoumarin; maleic anhydride
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kadhum, A.A.H.; Al-Amiery, A.A.; Musa, A.Y.; Mohamad, A.B. The Antioxidant Activity of New Coumarin Derivatives. Int. J. Mol. Sci. 2011, 12, 5747-5761.

AMA Style

Kadhum AAH, Al-Amiery AA, Musa AY, Mohamad AB. The Antioxidant Activity of New Coumarin Derivatives. International Journal of Molecular Sciences. 2011; 12(9):5747-5761.

Chicago/Turabian Style

Kadhum, Abdul Amir H.; Al-Amiery, Ahmed A.; Musa, Ahmed Y.; Mohamad, Abu Bakar. 2011. "The Antioxidant Activity of New Coumarin Derivatives." Int. J. Mol. Sci. 12, no. 9: 5747-5761.


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