Int. J. Mol. Sci. 2011, 12(8), 5373-5389; doi:10.3390/ijms12085373
Review

p66Shc Aging Protein in Control of Fibroblasts Cell Fate

1,2email, 3email, 1email, 2email, 1email, 4email, 1email, 3email, 2email and 1,* email
Received: 6 July 2011; in revised form: 2 August 2011 / Accepted: 15 August 2011 / Published: 22 August 2011
(This article belongs to the Special Issue Oxidative Stress and Mitochondria)
View Full-Text   |   Download PDF [586 KB, uploaded 19 June 2014]
Abstract: Reactive oxygen species (ROS) are wieldy accepted as one of the main factors of the aging process. These highly reactive compounds modify nucleic acids, proteins and lipids and affect the functionality of mitochondria in the first case and ultimately of the cell. Any agent or genetic modification that affects ROS production and detoxification can be expected to influence longevity. On the other hand, genetic manipulations leading to increased longevity can be expected to involve cellular changes that affect ROS metabolism. The 66-kDa isoform of the growth factor adaptor Shc (p66Shc) has been recognized as a relevant factor to the oxygen radical theory of aging. The most recent data indicate that p66Shc protein regulates life span in mammals and its phosphorylation on serine 36 is important for the initiation of cell death upon oxidative stress. Moreover, there is strong evidence that apart from aging, p66Shc may be implicated in many oxidative stress-associated pathologies, such as diabetes, mitochondrial and neurodegenerative disorders and tumorigenesis. This article summarizes recent knowledge about the role of p66Shc in aging and senescence and how this protein can influence ROS production and detoxification, focusing on studies performed on skin and skin fibroblasts.
Keywords: p66Shc; reactive oxygen species; antioxidant defense; mitochondria
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Suski, J.M.; Karkucinska-Wieckowska, A.; Lebiedzinska, M.; Giorgi, C.; Szczepanowska, J.; Szabadkai, G.; Duszynski, J.; Pronicki, M.; Pinton, P.; Wieckowski, M.R. p66Shc Aging Protein in Control of Fibroblasts Cell Fate. Int. J. Mol. Sci. 2011, 12, 5373-5389.

AMA Style

Suski JM, Karkucinska-Wieckowska A, Lebiedzinska M, Giorgi C, Szczepanowska J, Szabadkai G, Duszynski J, Pronicki M, Pinton P, Wieckowski MR. p66Shc Aging Protein in Control of Fibroblasts Cell Fate. International Journal of Molecular Sciences. 2011; 12(8):5373-5389.

Chicago/Turabian Style

Suski, Jan M.; Karkucinska-Wieckowska, Agnieszka; Lebiedzinska, Magdalena; Giorgi, Carlotta; Szczepanowska, Joanna; Szabadkai, Gyorgy; Duszynski, Jerzy; Pronicki, Maciej; Pinton, Paolo; Wieckowski, Mariusz R. 2011. "p66Shc Aging Protein in Control of Fibroblasts Cell Fate." Int. J. Mol. Sci. 12, no. 8: 5373-5389.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert