FK506-Binding Protein 22 from a Psychrophilic Bacterium, a Cold Shock-Inducible Peptidyl Prolyl Isomerase with the Ability to Assist in Protein Folding
Abstract
:1. Introduction
2. Shewanella sp. SIB1 as a Psychrophilic Bacterium
3. SIB1 FKBP22 as a Cold Shock Protein
4. Characterization of the Activity and Stability of SIB1 FKBP22 as a Cold-Adapted Enzyme
4.1. PPIase Activity of SIB1 FKBP22
4.2. Stability of SIB1 FKBP22
4.3. Relationship between Activity and Stability of SIB1 FKBP22
5. Involvement of SIB1 FKBP22 in Protein Folding
5.1. SIB1 FKBP22 as a Foldase
5.2. SIB1 FKBP22 as a Chaperone
5.3. The Relationship between Foldase and Chaperone Activities
6. A Possible Role of SIB1 FKBP22 in Cold Adaptation
7. Other PPIases and Involvement in Cold Adaptation
8. Conclusions
Acknowledgments
References
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Protein | Transition | Tm (°C) |
---|---|---|
SIB1 FKBP22 | First | 32.5 |
Second | 46.4 | |
C-domain+ | 35.6 | |
N-domain+ | 44.4 |
KD Values (μM) | |
---|---|
SIB1 FKBP22 | 2.2 |
N-domain+ | 3.4 |
C-domain+ | not detected |
NNC-FKBP22 | 14.4 |
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Budiman, C.; Koga, Y.; Takano, K.; Kanaya, S. FK506-Binding Protein 22 from a Psychrophilic Bacterium, a Cold Shock-Inducible Peptidyl Prolyl Isomerase with the Ability to Assist in Protein Folding. Int. J. Mol. Sci. 2011, 12, 5261-5284. https://doi.org/10.3390/ijms12085261
Budiman C, Koga Y, Takano K, Kanaya S. FK506-Binding Protein 22 from a Psychrophilic Bacterium, a Cold Shock-Inducible Peptidyl Prolyl Isomerase with the Ability to Assist in Protein Folding. International Journal of Molecular Sciences. 2011; 12(8):5261-5284. https://doi.org/10.3390/ijms12085261
Chicago/Turabian StyleBudiman, Cahyo, Yuichi Koga, Kazufumi Takano, and Shigenori Kanaya. 2011. "FK506-Binding Protein 22 from a Psychrophilic Bacterium, a Cold Shock-Inducible Peptidyl Prolyl Isomerase with the Ability to Assist in Protein Folding" International Journal of Molecular Sciences 12, no. 8: 5261-5284. https://doi.org/10.3390/ijms12085261