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Int. J. Mol. Sci. 2011, 12(8), 5187-5199; doi:10.3390/ijms12085187
Article

Syntheses and Self-assembling Behaviors of Pentagonal Conjugates of Tryptophane Zipper-Forming Peptide

1,2,* , 1 and 1,2
1 Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka 819-0395, Japan 2 International Research Center for Molecular Systems, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka 819-0395, Japan
* Author to whom correspondence should be addressed.
Received: 13 June 2011 / Revised: 30 July 2011 / Accepted: 10 August 2011 / Published: 15 August 2011
(This article belongs to the Special Issue Molecular Self-Assembly 2011)
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Abstract

Pentagonal conjugates of tryptophane zipper-forming peptide (CKTWTWTE) with a pentaazacyclopentadecane core (Pentagonal-Gly-Trpzip and Pentagonal-Ala-Trpzip) were synthesized and their self-assembling behaviors were investigated in water. Pentagonal-Gly-Trpzip self-assembled into nanofibers with the width of about 5 nm in neutral water (pH 7) via formation of tryptophane zipper, which irreversibly converted to nanoribbons by heating. In contrast, Pentagonal-Ala-Trpzip formed irregular aggregates in water.
Keywords: pentagonal conjugate; tryptophane zipper peptide; self-assembly; nanofiber pentagonal conjugate; tryptophane zipper peptide; self-assembly; nanofiber
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Matsuura, K.; Murasato, K.; Kimizuka, N. Syntheses and Self-assembling Behaviors of Pentagonal Conjugates of Tryptophane Zipper-Forming Peptide. Int. J. Mol. Sci. 2011, 12, 5187-5199.

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