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Characterization and Degradation Behavior of Agar–Carbomer Based Hydrogels for Drug Delivery Applications: Solute Effect
Dipartimento di Chimica, Materiali e Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy
Dipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche “Mario Negri”, via La Masa 19, 20156 Milano, Italy
* Author to whom correspondence should be addressed.
Received: 13 April 2011; in revised form: 18 May 2011 / Accepted: 19 May 2011 / Published: 25 May 2011
Abstract: In this study hydrogels synthesized from agarose and carbomer 974P macromers were selected for their potential application in spinal cord injury (SCI) repair strategies following their ability to carry cells and drugs. Indeed, in drug delivery applications, one of the most important issues to be addressed concerns hydrogel ability to provide a finely controlled delivery of loaded drugs, together with a coherent degradation kinetic. Nevertheless, solute effects on drug delivery system are often neglected in the large body of literature, focusing only on the characterization of unloaded matrices. For this reason, in this work, hydrogels were loaded with a chromophoric salt able to mimic, in terms of steric hindrance, many steroids commonly used in SCI repair, and its effects were investigated both from a structural and a rheological point of view, considering the pH-sensitivity of the material. Additionally, degradation chemistry was assessed by means of infrared bond response (FT-IR) and mass loss.
Keywords: degradation; drug effect; FT-IR; hydrogels; rheology
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Rossi, F.; Santoro, M.; Casalini, T.; Veglianese, P.; Masi, M.; Perale, G. Characterization and Degradation Behavior of Agar–Carbomer Based Hydrogels for Drug Delivery Applications: Solute Effect. Int. J. Mol. Sci. 2011, 12, 3394-3408.
Rossi F, Santoro M, Casalini T, Veglianese P, Masi M, Perale G. Characterization and Degradation Behavior of Agar–Carbomer Based Hydrogels for Drug Delivery Applications: Solute Effect. International Journal of Molecular Sciences. 2011; 12(6):3394-3408.
Rossi, Filippo; Santoro, Marco; Casalini, Tommaso; Veglianese, Pietro; Masi, Maurizio; Perale, Giuseppe. 2011. "Characterization and Degradation Behavior of Agar–Carbomer Based Hydrogels for Drug Delivery Applications: Solute Effect." Int. J. Mol. Sci. 12, no. 6: 3394-3408.