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Int. J. Mol. Sci. 2011, 12(4), 2750-2756; doi:10.3390/ijms12042750
Article

Antimicrobial Activities of Hexane Extract and Decussatin from Stembark Extract of Ficus congensis

1,* , 2
, 1
, 1
, 3
, 4
 and 5
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, Lagos, 234, Nigeria 2 School of Chemistry, University of Kwazulu Natal, Westvile, P/Mail Bag X54001, Durban, 4000, South Africa 3 Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Lagos, 234, Nigeria 4 School of Biological Studies, University of Kwazulu Natal, Westvile, P/Mail Bag X54001, Durban, 4000, South Africa 5 Department of Mycology, College of Medicine, Lagos University Teaching Hospital, Lagos, 234, Nigeria
* Author to whom correspondence should be addressed.
Received: 9 February 2011 / Revised: 28 March 2011 / Accepted: 12 April 2011 / Published: 21 April 2011
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Ficus congensis (Moraceae) is used traditionally in the treatment of various diseases including infectious diseases, infertility, and gastrointestinal disorders. Investigation of hexane extract of the stem bark using chromatographic techniques led to isolation of a xanthone, 1-hydroxy-3,7,8-trimethoxyxanthone (Decussatin). The compound was elucidated based on spectroscopic methods such as nuclear magnetic resonance (NMR), UV, IR, and mass spectrometry (MS). Decussatin and the hexane extract were screened in vitro for antibacterial and antifungal activities using broth microdilution (MHB) and disc Agar diffusion (DAD) techniques against Escheichia coli, Bacilus substilis, Klebsiela pneumonia, Staphylococcus aureus, Aspergillus fumigatus, Trichophyton mentagrophytes, Trichophyton rubrum and Candida albicans. Hexane extracts showed potent antibacterial activity against E. coli and B. subtilis with minimum inhibitory concentrations (MIC) of 8 mg/mL and 5 mg/mL, respectively, while Decussatin of the highest concentration (8 mg/mL) used in this study showed no appreciable antimicrobial activity. Only hexane extract was active against C. albicans with a MIC of 1 mg/mL.
Keywords: Moraceae; Ficus congensis; decussatin; antimicrobial; DAD; MHB Moraceae; Ficus congensis; decussatin; antimicrobial; DAD; MHB
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Alaribe, C.S.; Shode, F.; Coker, H.A.B.; Ayoola, G.; Sunday, A.; Singh, N.; Iwuanyanwu, S. Antimicrobial Activities of Hexane Extract and Decussatin from Stembark Extract of Ficus congensis. Int. J. Mol. Sci. 2011, 12, 2750-2756.

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