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Antimicrobial Activities of Hexane Extract and Decussatin from Stembark Extract of Ficus congensis
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, Lagos, 234, Nigeria
School of Chemistry, University of Kwazulu Natal, Westvile, P/Mail Bag X54001, Durban, 4000, South Africa
Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Lagos, 234, Nigeria
School of Biological Studies, University of Kwazulu Natal, Westvile, P/Mail Bag X54001, Durban, 4000, South Africa
Department of Mycology, College of Medicine, Lagos University Teaching Hospital, Lagos, 234, Nigeria
* Author to whom correspondence should be addressed.
Received: 9 February 2011; in revised form: 28 March 2011 / Accepted: 12 April 2011 / Published: 21 April 2011
Abstract: Ficus congensis (Moraceae) is used traditionally in the treatment of various diseases including infectious diseases, infertility, and gastrointestinal disorders. Investigation of hexane extract of the stem bark using chromatographic techniques led to isolation of a xanthone, 1-hydroxy-3,7,8-trimethoxyxanthone (Decussatin). The compound was elucidated based on spectroscopic methods such as nuclear magnetic resonance (NMR), UV, IR, and mass spectrometry (MS). Decussatin and the hexane extract were screened in vitro for antibacterial and antifungal activities using broth microdilution (MHB) and disc Agar diffusion (DAD) techniques against Escheichia coli, Bacilus substilis, Klebsiela pneumonia, Staphylococcus aureus, Aspergillus fumigatus, Trichophyton mentagrophytes, Trichophyton rubrum and Candida albicans. Hexane extracts showed potent antibacterial activity against E. coli and B. subtilis with minimum inhibitory concentrations (MIC) of 8 mg/mL and 5 mg/mL, respectively, while Decussatin of the highest concentration (8 mg/mL) used in this study showed no appreciable antimicrobial activity. Only hexane extract was active against C. albicans with a MIC of 1 mg/mL.
Keywords: Moraceae; Ficus congensis; decussatin; antimicrobial; DAD; MHB
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MDPI and ACS Style
Alaribe, C.S.; Shode, F.; Coker, H.A.B.; Ayoola, G.; Sunday, A.; Singh, N.; Iwuanyanwu, S. Antimicrobial Activities of Hexane Extract and Decussatin from Stembark Extract of Ficus congensis. Int. J. Mol. Sci. 2011, 12, 2750-2756.
Alaribe CS, Shode F, Coker HAB, Ayoola G, Sunday A, Singh N, Iwuanyanwu S. Antimicrobial Activities of Hexane Extract and Decussatin from Stembark Extract of Ficus congensis. International Journal of Molecular Sciences. 2011; 12(4):2750-2756.
Alaribe, Chinwendum Stephenie; Shode, Francis; Coker, Herbert A. B.; Ayoola, Gloria; Sunday, Adesegun; Singh, Nisha; Iwuanyanwu, Silva. 2011. "Antimicrobial Activities of Hexane Extract and Decussatin from Stembark Extract of Ficus congensis." Int. J. Mol. Sci. 12, no. 4: 2750-2756.