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Int. J. Mol. Sci. 2011, 12(4), 2618-2630; doi:10.3390/ijms12042618

Antioxidant Effects of the Ethanol Extract from Flower of Camellia japonica via Scavenging of Reactive Oxygen Species and Induction of Antioxidant Enzymes

1
School of Medicine and Applied Radiological Science Research Institute, Jeju National University, Jeju 690–756, Korea
2
Amore Pacific Co. R&D Center, Yongin-si, Gyeonggi-do 446–729, Korea
*
Author to whom correspondence should be addressed.
Received: 24 March 2011 / Revised: 11 April 2011 / Accepted: 12 April 2011 / Published: 18 April 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The aim of this study was to investigate the antioxidant properties of the ethanol extract of the flower of Camellia japonica (Camellia extract). Camellia extract exhibited 1,1-diphenyl-2-picrylhydrazyl radical and intracellular reactive oxygen species (ROS) scavenging activity in human HaCaT keratinocytes. In addition, Camellia extract scavenged superoxide anion generated by xanthine/xanthine oxidase and hydroxyl radical generated by the Fenton reaction (FeSO4 + H2O2) in a cell-free system, which was detected by electron spin resonance spectrometry. Furthermore, Camellia extract increased the protein expressions and activity of cellular antioxidant enzymes, such as superoxide dismutase, catalase and glutathione peroxidase. These results suggest that Camellia extract exhibits antioxidant properties by scavenging ROS and enhancing antioxidant enzymes. Camellia extract contained quercetin, quercetin-3-O-glucoside, quercitrin and kaempferol, which are antioxidant compounds.
Keywords: antioxidant effect; Camellia japonica; reactive oxygen species antioxidant effect; Camellia japonica; reactive oxygen species
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Piao, M.J.; Yoo, E.S.; Koh, Y.S.; Kang, H.K.; Kim, J.; Kim, Y.J.; Kang, H.H.; Hyun, J.W. Antioxidant Effects of the Ethanol Extract from Flower of Camellia japonica via Scavenging of Reactive Oxygen Species and Induction of Antioxidant Enzymes. Int. J. Mol. Sci. 2011, 12, 2618-2630.

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