Next Article in Journal
Cloning, Soluble Expression and Purification of High Yield Recombinant hGMCSF in Escherichia coli
Next Article in Special Issue
The Role of microRNAs in the Biology of Rare Diseases
Previous Article in Journal
Recent Advances in Conjugated Polymers for Light Emitting Devices
Previous Article in Special Issue
Screening of Molecular Virulence Markers in Staphylococcus aureus and Pseudomonas aeruginosa Strains Isolated from Clinical Infections
Int. J. Mol. Sci. 2011, 12(3), 2055-2063; doi:10.3390/ijms12032055
Review

Circulating MicroRNAs: Potential Biomarkers for Cancer

1,2
, 1
, 1
 and 1,2,*
Received: 21 December 2010; in revised form: 10 February 2011 / Accepted: 10 March 2011 / Published: 22 March 2011
(This article belongs to the Special Issue Advances in Molecular Diagnostics)
View Full-Text   |   Download PDF [112 KB, uploaded 19 June 2014]
Abstract: Cancer is the leading cause of death in the world. Development of minimally invasive biomarkers for early detection of cancer is urgently needed to reduce high morbidity and mortality associated with malignancy. MicroRNAs (miRNAs) are small regulatory RNAs that modulate the activity of specific mRNA targets and play important roles in a wide range of physiologic and pathologic processes. Recently, miRNAs were found to be dysregulated in a variety of diseases including cancer. Emerging evidence suggests that miRNAs are involved in tumor initiation and progression. Together, the different expression profiles of miRNAs in cancer, and the stability of circulating miRNAs, make them new potentially clinical biomarkers for cancer diagnosis, classification, therapeutic decisions, and prognosis.
Keywords: circulation; microrna; neoplasm; biomarkers circulation; microrna; neoplasm; biomarkers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Yu, D.-C.; Li, Q.-G.; Ding, X.-W.; Ding, Y.-T. Circulating MicroRNAs: Potential Biomarkers for Cancer. Int. J. Mol. Sci. 2011, 12, 2055-2063.

AMA Style

Yu D-C, Li Q-G, Ding X-W, Ding Y-T. Circulating MicroRNAs: Potential Biomarkers for Cancer. International Journal of Molecular Sciences. 2011; 12(3):2055-2063.

Chicago/Turabian Style

Yu, De-Cai; Li, Qing-Guo; Ding, Xi-Wei; Ding, Yi-Tao. 2011. "Circulating MicroRNAs: Potential Biomarkers for Cancer." Int. J. Mol. Sci. 12, no. 3: 2055-2063.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert