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Chitin-based Materials in Tissue Engineering: Applications in Soft Tissue and Epithelial Organ
Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, Taipei, 100, Taiwan
Department of Otolaryngology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan
Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, 100, Taiwan
Received: 14 February 2011; in revised form: 7 March 2011 / Accepted: 8 March 2011 / Published: 17 March 2011
Abstract: Chitin-based materials and their derivatives are receiving increased attention in tissue engineering because of their unique and appealing biological properties. In this review, we summarize the biomedical potential of chitin-based materials, specifically focusing on chitosan, in tissue engineering approaches for epithelial and soft tissues. Both types of tissues play an important role in supporting anatomical structures and physiological functions. Because of the attractive features of chitin-based materials, many characteristics beneficial to tissue regeneration including the preservation of cellular phenotype, binding and enhancement of bioactive factors, control of gene expression, and synthesis and deposition of tissue-specific extracellular matrix are well-regulated by chitin-based scaffolds. These scaffolds can be used in repairing body surface linings, reconstructing tissue structures, regenerating connective tissue, and supporting nerve and vascular growth and connection. The novel use of these scaffolds in promoting the regeneration of various tissues originating from the epithelium and soft tissue demonstrates that these chitin-based materials have versatile properties and functionality and serve as promising substrates for a great number of future applications.
Keywords: chitin; chitosan; epithelium; soft tissue; tissue engineering; regeneration
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MDPI and ACS Style
Yang, T.-L. Chitin-based Materials in Tissue Engineering: Applications in Soft Tissue and Epithelial Organ. Int. J. Mol. Sci. 2011, 12, 1936-1963.
Yang T-L. Chitin-based Materials in Tissue Engineering: Applications in Soft Tissue and Epithelial Organ. International Journal of Molecular Sciences. 2011; 12(3):1936-1963.
Yang, Tsung-Lin. 2011. "Chitin-based Materials in Tissue Engineering: Applications in Soft Tissue and Epithelial Organ." Int. J. Mol. Sci. 12, no. 3: 1936-1963.