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Int. J. Mol. Sci. 2011, 12(3), 1505-1518; doi:10.3390/ijms12031505

IL8 and Cathepsin B as Melanoma Serum Biomarkers

1,* , 1
1 Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA 2 Division of Hematology-Oncology, HUP, 16 Penn Tower, Philadelphia, PA 19104, USA 3 The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104, USA
* Author to whom correspondence should be addressed.
Received: 3 December 2010 / Revised: 15 February 2011 / Accepted: 22 February 2011 / Published: 25 February 2011
(This article belongs to the Special Issue Biomarkers)
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Melanoma accounts for only a small portion of skin cancer but it is associated with high mortality. Melanoma serum biomarkers that may aid early diagnosis or guide therapy are needed clinically. However, studies of serum biomarkers have often been hampered by the serum interference that causes false readouts in immunological tests. Here we show that, after using a special buffer to eliminate the serum interference, IL-8 and cathepsin B levels were significantly elevated in melanoma patients (p < 0.05). More importantly, the combination of IL-8 and cathepsin B were also studied as a prognosis marker for melanoma mortality. Our study provides a novel approach to examine serum biomarkers.
Keywords: IL-8; cathepsin B; melanoma; serum interference IL-8; cathepsin B; melanoma; serum interference
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, H.; Fu, T.; McGettigan, S.; Kumar, S.; Liu, S.; Speicher, D.; Schuchter, L.; Xu, X. IL8 and Cathepsin B as Melanoma Serum Biomarkers. Int. J. Mol. Sci. 2011, 12, 1505-1518.

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