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Int. J. Mol. Sci. 2011, 12(2), 1060-1065; doi:10.3390/ijms12021060

FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs

1,2,†,* , 1,3,†
,
1
and
1,*
1
Institute of Biomechanics, School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China
2
Nuolan Net, Wuhan 430071, China
3
School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 28 December 2010 / Revised: 17 January 2011 / Accepted: 19 January 2011 / Published: 8 February 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

FurinDB (freely available online at http://www.nuolan.net/substrates.html) is a database of furin substrates. This database includes experimentally verified furin cleavage sites, substrates, species, experimental methods, original publications of experiments and associated drugs targeting furin substrates. The current database release contains 126 furin cleavage sites from three species: mammals, bacteria and viruses. A main feature of this database is that all furin cleavage sites are recorded as a 20-residue motif, including one core region (eight amino acids, P6–P2’) and two flanking solvent accessible regions (eight amino acids, P7–P14, and four amino acids, P3’–P6’), that represent our current understanding of the molecular biology of furin cleavage. This database is important for understanding the molecular evolution and relationships between sequence motifs, 3D structures, cellular functions and physical properties required by furin for cleavage, and for elucidating the molecular mechanisms and the progression of furin cleavage associated human diseases, including pathogenic infections, neurological disorders, tumorigenesis, tumor invasion, angiogenesis, and metastasis. FurinDB database will be a solid addition to the publicly available infrastructure for scientists in the field of molecular biology.
Keywords: furin; furin cleavage site; molecular database furin; furin cleavage site; molecular database
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Tian, S.; Huang, Q.; Fang, Y.; Wu, J. FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs. Int. J. Mol. Sci. 2011, 12, 1060-1065.

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