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Int. J. Mol. Sci. 2011, 12(2), 1030-1040; doi:10.3390/ijms12021030
Article

Chemically Induced Breast Tumors in Rats Are Detectable in Early Stages by Contrast Enhanced Magnetic Resonance Imaging but Not by Changes in the Acute-Phase Reactants in Serum

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Received: 20 December 2010 / Revised: 4 February 2011 / Accepted: 4 February 2011 / Published: 7 February 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The present study was undertaken to develop a rat model for monitoring the early development of breast cancer. Twelve female rats were divided into two groups of six rats that were either treated with N-methyl-N-nitrosourea to induce breast cancer or with bacterial lipopolysaccharide to induce inflammation. Serum samples taken from the rats prior to the treatment were used as controls. By the 14th week, presence of the tumor was detectable by contrast enhanced magnetic resonance imaging and confirmed by histopathology. When the serum proteins of the rats were examined by 2-dimensional electrophoresis (2-DE), no difference could be detected in the profiles of all proteins before and 18 weeks after administration of N-methyl-N-nitrosourea. However, higher expression of alpha-1B glycoprotein was detectable by 2-DE in serum samples of rats at the 18th week post-treatment with lipopolysaccharide.
Keywords: acute-phase response; breast cancer; proteomics; magnetic resonance imaging acute-phase response; breast cancer; proteomics; magnetic resonance imaging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Golbabapour, S.; Pang, W.W.; George, J.; Pasupati, T.; Abdul-Rahman, P.S.; Hashim, O.H. Chemically Induced Breast Tumors in Rats Are Detectable in Early Stages by Contrast Enhanced Magnetic Resonance Imaging but Not by Changes in the Acute-Phase Reactants in Serum. Int. J. Mol. Sci. 2011, 12, 1030-1040.

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