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Int. J. Mol. Sci. 2011, 12(12), 8787-8796; doi:10.3390/ijms12128787
Communication

Melanogenesis Inhibitory Activity of Two Generic Drugs: Cinnarizine and Trazodone in Mouse B16 Melanoma Cells

1,*  and 2,3
1 Department of Biological Science and Technology, National University of Tainan, 33 Sec. 2 Su-Lin St., Tainan 71702, Taiwan 2 Department of Urology, E-Da Hospital, Kaohsiung 84001, Taiwan 3 The PhD Program of Biotechnology, Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung 84001, Taiwan
* Author to whom correspondence should be addressed.
Received: 21 October 2011 / Revised: 26 November 2011 / Accepted: 28 November 2011 / Published: 2 December 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

More than 200 generic drugs were screened to identify the inhibitory activity on melanogenesis in mouse B16 melanoma cells. Cinnarizine and trazodone were identified as melanogenesis inhibitors. The inhibitory effects of the two drugs on cell survival, melanogenesis, and tyrosinase activity were investigated. The results showed that both cinnarizine and trazodone inhibited melanogenesis in B16 cells by a dose-dependent manner at the non-cytotoxic concentrations. Based on the results of the present study, seeking new melanogenesis inhibitors from generic drugs is an alternative approach to developing new depigmenting agents in cosmeceuticals. Moreover, cinnarizine and trazodone were proven to be good candidates as skin-whitening agents for treatment of skin hyperpigmentation.
Keywords: cinnarizine; inhibition; melanogenesis; trazodone; tyrosinase cinnarizine; inhibition; melanogenesis; trazodone; tyrosinase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chang, T.-S.; Lin, V.-H. Melanogenesis Inhibitory Activity of Two Generic Drugs: Cinnarizine and Trazodone in Mouse B16 Melanoma Cells. Int. J. Mol. Sci. 2011, 12, 8787-8796.

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