Int. J. Mol. Sci. 2011, 12(12), 8787-8796; doi:10.3390/ijms12128787
Communication

Melanogenesis Inhibitory Activity of Two Generic Drugs: Cinnarizine and Trazodone in Mouse B16 Melanoma Cells

Received: 21 October 2011; in revised form: 26 November 2011 / Accepted: 28 November 2011 / Published: 2 December 2011
(This article belongs to the Section Bioactives and Nutraceuticals)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: More than 200 generic drugs were screened to identify the inhibitory activity on melanogenesis in mouse B16 melanoma cells. Cinnarizine and trazodone were identified as melanogenesis inhibitors. The inhibitory effects of the two drugs on cell survival, melanogenesis, and tyrosinase activity were investigated. The results showed that both cinnarizine and trazodone inhibited melanogenesis in B16 cells by a dose-dependent manner at the non-cytotoxic concentrations. Based on the results of the present study, seeking new melanogenesis inhibitors from generic drugs is an alternative approach to developing new depigmenting agents in cosmeceuticals. Moreover, cinnarizine and trazodone were proven to be good candidates as skin-whitening agents for treatment of skin hyperpigmentation.
Keywords: cinnarizine; inhibition; melanogenesis; trazodone; tyrosinase
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MDPI and ACS Style

Chang, T.-S.; Lin, V.-H. Melanogenesis Inhibitory Activity of Two Generic Drugs: Cinnarizine and Trazodone in Mouse B16 Melanoma Cells. Int. J. Mol. Sci. 2011, 12, 8787-8796.

AMA Style

Chang T-S, Lin V-H. Melanogenesis Inhibitory Activity of Two Generic Drugs: Cinnarizine and Trazodone in Mouse B16 Melanoma Cells. International Journal of Molecular Sciences. 2011; 12(12):8787-8796.

Chicago/Turabian Style

Chang, Te-Sheng; Lin, Victor Chia-Hsiang. 2011. "Melanogenesis Inhibitory Activity of Two Generic Drugs: Cinnarizine and Trazodone in Mouse B16 Melanoma Cells." Int. J. Mol. Sci. 12, no. 12: 8787-8796.

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