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Int. J. Mol. Sci. 2011, 12(12), 8333-8346; doi:10.3390/ijms12128333
Article

Inhibition of Extracellular Signal-Regulated Kinases Ameliorates Hypertension-Induced Renal Vascular Remodeling in Rat Models

1,2
, 1,* , 1
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 and 2,*
Received: 26 August 2011; in revised form: 19 September 2011 / Accepted: 21 October 2011 / Published: 28 November 2011
(This article belongs to the Special Issue Advances in Molecular Neuropathology)
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Abstract: The aim of this study is to investigate the effect of the extracellular signal-regulated kinases 1/2 (ERK1/2) inhibitor, PD98059, on high blood pressure and related vascular changes. Blood pressure was recorded, thicknesses of renal small artery walls were measured and ERK1/2 immunoreactivity and erk2 mRNA in renal vascular smooth muscle cells (VSMCs) and endothelial cells were detected by immunohistochemistry and in situ hybridization in normotensive wistar kyoto (WKY) rats, spontaneously hypertensive rats (SHR) and PD98059-treated SHR. Compared with normo-tensive WKY rats, SHR developed hypertension at 8 weeks of age, thickened renal small artery wall and asymmetric arrangement of VSMCs at 16 and 24 weeks of age. Phospho-ERK1/2 immunoreactivity and erk2 mRNA expression levels were increased in VSMCs and endothelial cells of the renal small arteries in the SHR. Treating SHR with PD98059 reduced the spontaneous hypertension-induced vascular wall thickening. This effect was associated with suppressions of erk2 mRNA expression and ERK1/2 phosphorylation in VSMCs and endothelial cells of the renal small arteries. It is concluded that inhibition of ERK1/2 ameliorates hypertension induced vascular remodeling in renal small arteries.
Keywords: artery; extracellular signal-regulated kinase; hypertension; kidney SHR; vascular remodeling artery; extracellular signal-regulated kinase; hypertension; kidney SHR; vascular remodeling
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Jing, L.; Zhang, J.; Sun, J.; Guo, F.; An, X.; Yang, K.; Li, P.A. Inhibition of Extracellular Signal-Regulated Kinases Ameliorates Hypertension-Induced Renal Vascular Remodeling in Rat Models. Int. J. Mol. Sci. 2011, 12, 8333-8346.

AMA Style

Jing L, Zhang J, Sun J, Guo F, An X, Yang K, Li PA. Inhibition of Extracellular Signal-Regulated Kinases Ameliorates Hypertension-Induced Renal Vascular Remodeling in Rat Models. International Journal of Molecular Sciences. 2011; 12(12):8333-8346.

Chicago/Turabian Style

Jing, Li; Zhang, Jianzhong; Sun, Jinping; Guo, Fengying; An, Xin; Yang, Kan; Li, Ping Andy. 2011. "Inhibition of Extracellular Signal-Regulated Kinases Ameliorates Hypertension-Induced Renal Vascular Remodeling in Rat Models." Int. J. Mol. Sci. 12, no. 12: 8333-8346.



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