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Int. J. Mol. Sci. 2011, 12(11), 8096-8104; doi:10.3390/ijms12118096

Protective Effects of Polysaccharides from Soybean Meal Against X-ray Radiation Induced Damage in Mouse Spleen Lymphocytes

1
School of Food Science and Engineering, Harbin Institute of Technology, 73 HuangHe Road, NanGang District, Harbin 150090, China
2
National Research Center of Soybean Engineering and Technology, Northeast Agriculture University, 201 GongBin Road, XiangFang District, Harbin 150030, China
3
School of Forestry, Northeast Forestry University, 26 HeXing Road, DongLi District, Harbin 150040, China
4
Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115-5737, USA
*
Author to whom correspondence should be addressed.
Received: 21 October 2011 / Revised: 8 November 2011 / Accepted: 9 November 2011 / Published: 17 November 2011
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Abstract

The aim of this study was to investigate radioprotective effect of the polysaccharides from soybean meal (SMP) against X-ray radiation-induced damage in mouse spleen lymphocytes. MTT and comet assay were performed to evaluate SMP’s ability to prevent cell death and DNA damage induced by radiation. The results show that, X-ray radiation (30 KV, 10 mA, 8 min (4 Gy)) can significantly increase cell death and DNA fragmentation of mouse spleen lymphocytes. Pretreatment with SMP for 2 h before radiation could increase cell viability, moreover, the SMP can reduce X-ray radiation-induced DNA damage. The percentage of tail DNA and the tail moment of the SMP groups were significantly lower than those of the radiation alone group (p < 0.05). These results suggest SMP may be a good candidate as a radioprotective agent. View Full-Text
Keywords: soybean meal polysaccharides; spleen lymphocytes; radioprotective; comet assay soybean meal polysaccharides; spleen lymphocytes; radioprotective; comet assay
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yao, L.; Wang, Z.; Zhao, H.; Cheng, C.; Fu, X.; Liu, J.; Yang, X. Protective Effects of Polysaccharides from Soybean Meal Against X-ray Radiation Induced Damage in Mouse Spleen Lymphocytes. Int. J. Mol. Sci. 2011, 12, 8096-8104.

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