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Int. J. Mol. Sci. 2011, 12(11), 7594-7608; doi:10.3390/ijms12117594
Article

Rice Protein Extracted by Different Methods Affects Cholesterol Metabolism in Rats Due to Its Lower Digestibility

1,2,* , 3
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4
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5,6
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7
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1
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1
 and
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1 School of Food Science and Engineering, Harbin Institute of Technology, 73 Huanghe Road, Harbin 150090, China 2 School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, China 3 Heilongjiang Provincial Environmental Monitoring Central Station, Harbin 150056, China 4 Heilongjiang Provincial Hospital, Harbin 150036, China 5 State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin 150090, China 6 School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China 7 College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China
* Author to whom correspondence should be addressed.
Received: 11 August 2011 / Revised: 18 October 2011 / Accepted: 1 November 2011 / Published: 7 November 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

To elucidate whether the digestibility is responsible for the hypocholesterolemic action of rice protein, the effects of rice proteins extracted by alkali (RP-A) and α-amylase (RP-E) on cholesterol metabolism were investigated in 7-week-old male Wistar rats fed cholesterol-free diets for 3 weeks. The in vitro and in vivo digestibility was significantly reduced by RP-A and RP-E as compared to casein (CAS). The digestibility was lower in RP-E than that of RP-A. Compared with CAS, the significant cholesterol-lowering effects were observed in rats fed by RP-A and RP-E. Fecal excretion of bile acids was significantly stimulated by RP-E, but not by RP-A. The apparent cholesterol absorption was more effectively inhibited by RP-E than RP-A because more fecal neutral sterols were excreted in rats fed RP-E. There was a significant correlation between protein digestibility and cholesterol absorption (r = 0.8662, P < 0.01), resulting in a significant correlation between protein digestibility and plasma cholesterol level (r = 0.7357, P < 0.01) in this study. The present study demonstrates that the digestibility of rice protein affected by extraction method plays a major role in the modulation of cholesterol metabolism. Results suggest that the hypocholesterolemic action induced by rice protein with lower digestibility primarily contribute to the inhibition of cholesterol absorption.
Keywords: rice protein; digestibility; cholesterol; absorption; rats rice protein; digestibility; cholesterol; absorption; rats
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Yang, L.; Chen, J.; Xu, T.; Qiu, W.; Zhang, Y.; Zhang, L.; Xu, F.; Liu, H. Rice Protein Extracted by Different Methods Affects Cholesterol Metabolism in Rats Due to Its Lower Digestibility. Int. J. Mol. Sci. 2011, 12, 7594-7608.

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