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Rice Protein Extracted by Different Methods Affects Cholesterol Metabolism in Rats Due to Its Lower Digestibility
School of Food Science and Engineering, Harbin Institute of Technology, 73 Huanghe Road, Harbin 150090, China
School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, China
Heilongjiang Provincial Environmental Monitoring Central Station, Harbin 150056, China
Heilongjiang Provincial Hospital, Harbin 150036, China
State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin 150090, China
School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China
* Author to whom correspondence should be addressed.
Received: 11 August 2011; in revised form: 18 October 2011 / Accepted: 1 November 2011 / Published: 7 November 2011
Abstract: To elucidate whether the digestibility is responsible for the hypocholesterolemic action of rice protein, the effects of rice proteins extracted by alkali (RP-A) and α-amylase (RP-E) on cholesterol metabolism were investigated in 7-week-old male Wistar rats fed cholesterol-free diets for 3 weeks. The in vitro and in vivo digestibility was significantly reduced by RP-A and RP-E as compared to casein (CAS). The digestibility was lower in RP-E than that of RP-A. Compared with CAS, the significant cholesterol-lowering effects were observed in rats fed by RP-A and RP-E. Fecal excretion of bile acids was significantly stimulated by RP-E, but not by RP-A. The apparent cholesterol absorption was more effectively inhibited by RP-E than RP-A because more fecal neutral sterols were excreted in rats fed RP-E. There was a significant correlation between protein digestibility and cholesterol absorption (r = 0.8662, P < 0.01), resulting in a significant correlation between protein digestibility and plasma cholesterol level (r = 0.7357, P < 0.01) in this study. The present study demonstrates that the digestibility of rice protein affected by extraction method plays a major role in the modulation of cholesterol metabolism. Results suggest that the hypocholesterolemic action induced by rice protein with lower digestibility primarily contribute to the inhibition of cholesterol absorption.
Keywords: rice protein; digestibility; cholesterol; absorption; rats
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MDPI and ACS Style
Yang, L.; Chen, J.; Xu, T.; Qiu, W.; Zhang, Y.; Zhang, L.; Xu, F.; Liu, H. Rice Protein Extracted by Different Methods Affects Cholesterol Metabolism in Rats Due to Its Lower Digestibility. Int. J. Mol. Sci. 2011, 12, 7594-7608.
Yang L, Chen J, Xu T, Qiu W, Zhang Y, Zhang L, Xu F, Liu H. Rice Protein Extracted by Different Methods Affects Cholesterol Metabolism in Rats Due to Its Lower Digestibility. International Journal of Molecular Sciences. 2011; 12(11):7594-7608.
Yang, Lin; Chen, Jiahou; Xu, Tong; Qiu, Wei; Zhang, Yan; Zhang, Lanwei; Xu, Fuping; Liu, Hongbo. 2011. "Rice Protein Extracted by Different Methods Affects Cholesterol Metabolism in Rats Due to Its Lower Digestibility." Int. J. Mol. Sci. 12, no. 11: 7594-7608.