Int. J. Mol. Sci. 2011, 12(10), 6881-6893; doi:10.3390/ijms12106881
Review

Malignant Catarrhal Fever: Understanding Molecular Diagnostics in Context of Epidemiology

Hong Li 1,2,* email, Cristina W. Cunha 1 email and Naomi S. Taus 1,2 email
1 Animal Disease Research Unit, USDA-Agricultural Research Service, Washington State University, Pullman, WA 99164, USA 2 Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA
* Author to whom correspondence should be addressed.
Received: 24 August 2011; in revised form: 22 September 2011 / Accepted: 10 October 2011 / Published: 18 October 2011
(This article belongs to the Special Issue Advances in Molecular Diagnostics)
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Abstract: Malignant catarrhal fever (MCF) is a frequently fatal disease, primarily of ruminants, caused by a group of gammaherpesviruses. Due to complexities of pathogenesis and epidemiology in various species, which are either clinically-susceptible or reservoir hosts, veterinary clinicians face significant challenges in laboratory diagnostics. The recent development of specific assays for viral DNA and antibodies has expanded and improved the inventory of laboratory tests and opened new opportunities for use of MCF diagnostics. Issues related to understanding and implementing appropriate assays for specific diagnostic needs must be addressed in order to take advantage of molecular diagnostics in the laboratory.
Keywords: malignant catarrhal fever; diagnosis; cELISA; PCR; gammaherpesvirus; infection

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Cite This Article

MDPI and ACS Style

Li, H.; Cunha, C.W.; Taus, N.S. Malignant Catarrhal Fever: Understanding Molecular Diagnostics in Context of Epidemiology. Int. J. Mol. Sci. 2011, 12, 6881-6893.

AMA Style

Li H, Cunha CW, Taus NS. Malignant Catarrhal Fever: Understanding Molecular Diagnostics in Context of Epidemiology. International Journal of Molecular Sciences. 2011; 12(10):6881-6893.

Chicago/Turabian Style

Li, Hong; Cunha, Cristina W.; Taus, Naomi S. 2011. "Malignant Catarrhal Fever: Understanding Molecular Diagnostics in Context of Epidemiology." Int. J. Mol. Sci. 12, no. 10: 6881-6893.

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