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Int. J. Mol. Sci. 2011, 12(10), 6881-6893; doi:10.3390/ijms12106881
Review

Malignant Catarrhal Fever: Understanding Molecular Diagnostics in Context of Epidemiology

1,2,* , 1
 and
1,2
Received: 24 August 2011 / Revised: 22 September 2011 / Accepted: 10 October 2011 / Published: 18 October 2011
(This article belongs to the Special Issue Advances in Molecular Diagnostics)
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Abstract

Malignant catarrhal fever (MCF) is a frequently fatal disease, primarily of ruminants, caused by a group of gammaherpesviruses. Due to complexities of pathogenesis and epidemiology in various species, which are either clinically-susceptible or reservoir hosts, veterinary clinicians face significant challenges in laboratory diagnostics. The recent development of specific assays for viral DNA and antibodies has expanded and improved the inventory of laboratory tests and opened new opportunities for use of MCF diagnostics. Issues related to understanding and implementing appropriate assays for specific diagnostic needs must be addressed in order to take advantage of molecular diagnostics in the laboratory.
Keywords: malignant catarrhal fever; diagnosis; cELISA; PCR; gammaherpesvirus; infection malignant catarrhal fever; diagnosis; cELISA; PCR; gammaherpesvirus; infection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, H.; Cunha, C.W.; Taus, N.S. Malignant Catarrhal Fever: Understanding Molecular Diagnostics in Context of Epidemiology. Int. J. Mol. Sci. 2011, 12, 6881-6893.

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