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Int. J. Mol. Sci. 2011, 12(10), 6517-6528; doi:10.3390/ijms12106517
Article

Characterization of Terpenoids from the Root of Ceriops tagal with Antifouling Activity

1,* , 1
, 2
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Received: 16 August 2011; in revised form: 27 September 2011 / Accepted: 28 September 2011 / Published: 6 October 2011
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: One new dimeric diterpenoid, 8(14)-enyl-pimar-2'(3')-en-4'(18')-en-15'(16')-en-dolabr-16,15,2',3'-oxoan-16-one (1) and five known terpenoids: Tagalsin C (2), Tagalsin I (3), lup-20(29)-ene-3β,28-diol (4), 3-oxolup-20(29)-en-28-oic acid (5) and 28-hydroxylup-20(29)-en-3-one (6) were isolated from the roots of the mangrove plant Ceriops tagal. Their structures and relative stereochemistry were elucidated by means of extensive NMR, IR and MS analysis. The antifouling activity against larval settlement of the barnacle Balanus albicostatus were evaluated using capsaicin as a positive control. All these terpenoids exhibited antifouling activity against cyprid larvae of the barnacle without significant toxicity. The structure-activity relationship results demonstrated that the order of antifouling activity was diterpenoid (Compound 2) > triterpenoid (Compounds 4, 5 and 6) > dimeric diterpenoid (Compounds 1 and 3). The functional groups on the C-28 position of lupane triterpenoid significantly affect the antifouling activity. The diterpenoid dimmer with two identical diterpenoid subunits might display more potent antifouling activity than one with two different diterpenoid subunits. The stability test showed that Compounds 2, 4, 5 and 6 remained stable over 2-month exposure under filtered seawater.
Keywords: terpenoids; antifouling activity; barnacle; Ceriops tagal; structure-activity relationship terpenoids; antifouling activity; barnacle; Ceriops tagal; structure-activity relationship
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, J.-D.; Yi, R.-Z.; Lin, Y.-M.; Feng, D.-Q.; Zhou, H.-C.; Wang, Z.-C. Characterization of Terpenoids from the Root of Ceriops tagal with Antifouling Activity. Int. J. Mol. Sci. 2011, 12, 6517-6528.

AMA Style

Chen J-D, Yi R-Z, Lin Y-M, Feng D-Q, Zhou H-C, Wang Z-C. Characterization of Terpenoids from the Root of Ceriops tagal with Antifouling Activity. International Journal of Molecular Sciences. 2011; 12(10):6517-6528.

Chicago/Turabian Style

Chen, Jun-De; Yi, Rui-Zao; Lin, Yi-Ming; Feng, Dan-Qing; Zhou, Hai-Chao; Wang, Zhan-Chang. 2011. "Characterization of Terpenoids from the Root of Ceriops tagal with Antifouling Activity." Int. J. Mol. Sci. 12, no. 10: 6517-6528.



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