Next Article in Journal
RNA Interference Targeting Slug Increases Cholangiocarcinoma Cell Sensitivity to Cisplatin via Upregulating PUMA
Previous Article in Journal
A Three-Dimensional, Magnetic and Electroactive Nanoprobe for Amperometric Determination of Tumor Biomarkers
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2011, 12(1), 376-384; doi:10.3390/ijms12010376

Effects of the Methanol Extract of Basella alba L (Basellaceae) on Steroid Production in Leydig Cells

Laboratory of Pharmacology and Toxicology, Department of Biochemistry, University of Yaoundé I, PO. Box 812 Yaounde, Cameroon
Biochemistry Laboratory-EA 2608-USC INRA 2006, IBFA, University of Caen, 14032, Caen, France
Department of Medical Biosciences, University of the Western Cape, South Africa
Author to whom correspondence should be addressed.
Received: 10 December 2010 / Revised: 21 December 2010 / Accepted: 8 January 2011 / Published: 14 January 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
View Full-Text   |   Download PDF [262 KB, uploaded 19 June 2014]   |  


In this study, Leydig cells were purified from 70 day-old Sprague Dawley male rats and incubated with 10 and 100 µg/mL of methanol extract of Basella alba (MEBa) for 4 hours followed by the evaluation of cell viability, steroid (testosterone and estradiol) production, and the level of aromatase mRNA. Results showed that MEBa did not affect Leydig cell viability. At the concentration of 10 µg/mL, MEBa significantly stimulated testosterone and estradiol production (p < 0.01 and p < 0.03, respectively), and enhanced aromatase mRNA level (p < 0.04). These observations suggest that MEBa directly stimulated testosterone, estradiol and aromatase mRNA levels in isolated Leydig cells. View Full-Text
Keywords: aromatase mRNA; Basella alba; estradiol; rat Leydig cells; testosterone aromatase mRNA; Basella alba; estradiol; rat Leydig cells; testosterone
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Nantia, E.A.; Travert, C.; Manfo, F.-P.; Carreau, S.; Monsees, T.K.; Fewou Moundipa, P. Effects of the Methanol Extract of Basella alba L (Basellaceae) on Steroid Production in Leydig Cells. Int. J. Mol. Sci. 2011, 12, 376-384.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top