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Int. J. Mol. Sci. 2010, 11(4), 1546-1556; doi:10.3390/ijms11041546
Article

Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite

*  and
Received: 12 March 2009; Accepted: 12 April 2010 / Published: 12 April 2010
(This article belongs to the Special Issue Composite Materials)
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Abstract: The preparation, characterization, and in vitro release of 5-aminosalicylic acid (5-ASA)from methacrylic acid (MAA)/perlite composites (APC) prepared via a sol–gel route are reported. The free-radical graft polymerization of methacrylic acid (MAA) onto perlite particles was studied experimentally. The grafting procedure consisted of surface activation with 3-(trimethoxysilyl) propyl methacrylate (TSPA), followed by free-radical graft polymerization of methacrylic acid (MAA) in ethyl acetate with 2,2΄-azobis-isobutyronitrile (AIBN) initiator. The composition of the composites hybrid materials was determined by FTIR spectroscopy. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). The dried composites were immersed in a saturated solution of 5-ASA in water overnight and dried over a period of three days at room temperature and the in vitro release profiles were established separately in both (SGF, pH 1) and (SIF, pH 7.4). The 5-ASA concentration of the solution was measured using a UV-Vis spectrophotometer (205 nm) at different time intervals. The in vitro drug release test revealed that the release rate of 5-ASA in buffer solutions increased with the silica content in the composites; on the contrary, the increase of the content of 3-(trimethoxysilyl)propyl methacrylate (TSPA), a coupling agent, decreased the drug release rate.
Keywords: methacrylic acid; perlite; silylation; polymerization; polymer grafting methacrylic acid; perlite; silylation; polymerization; polymer grafting
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mahkam, M.; Vakhshouri, L. Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite. Int. J. Mol. Sci. 2010, 11, 1546-1556.

AMA Style

Mahkam M, Vakhshouri L. Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite. International Journal of Molecular Sciences. 2010; 11(4):1546-1556.

Chicago/Turabian Style

Mahkam, Mehrdad; Vakhshouri, Laleh. 2010. "Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite." Int. J. Mol. Sci. 11, no. 4: 1546-1556.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert