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Int. J. Mol. Sci. 2010, 11(4), 1546-1556; doi:10.3390/ijms11041546

Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite

Chemistry Department, Azarbaijan University of Tarbiat Moallem, Tabriz, Iran
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Author to whom correspondence should be addressed.
Received: 12 March 2009 / Accepted: 12 April 2010 / Published: 12 April 2010
(This article belongs to the Special Issue Composite Materials)
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Abstract

The preparation, characterization, and in vitro release of 5-aminosalicylic acid (5-ASA)from methacrylic acid (MAA)/perlite composites (APC) prepared via a sol–gel route are reported. The free-radical graft polymerization of methacrylic acid (MAA) onto perlite particles was studied experimentally. The grafting procedure consisted of surface activation with 3-(trimethoxysilyl) propyl methacrylate (TSPA), followed by free-radical graft polymerization of methacrylic acid (MAA) in ethyl acetate with 2,2΄-azobis-isobutyronitrile (AIBN) initiator. The composition of the composites hybrid materials was determined by FTIR spectroscopy. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). The dried composites were immersed in a saturated solution of 5-ASA in water overnight and dried over a period of three days at room temperature and the in vitro release profiles were established separately in both (SGF, pH 1) and (SIF, pH 7.4). The 5-ASA concentration of the solution was measured using a UV-Vis spectrophotometer (205 nm) at different time intervals. The in vitro drug release test revealed that the release rate of 5-ASA in buffer solutions increased with the silica content in the composites; on the contrary, the increase of the content of 3-(trimethoxysilyl)propyl methacrylate (TSPA), a coupling agent, decreased the drug release rate. View Full-Text
Keywords: methacrylic acid; perlite; silylation; polymerization; polymer grafting methacrylic acid; perlite; silylation; polymerization; polymer grafting
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MDPI and ACS Style

Mahkam, M.; Vakhshouri, L. Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite. Int. J. Mol. Sci. 2010, 11, 1546-1556.

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