Int. J. Mol. Sci. 2010, 11(4), 1557-1579; doi:10.3390/ijms11041557

Chromatin Fiber Dynamics under Tension and Torsion

1,* email, 2 and 3,* email
Received: 3 December 2009; in revised form: 20 February 2010 / Accepted: 19 March 2010 / Published: 12 April 2010
(This article belongs to the Special Issue Single Molecules)
View Full-Text   |   Download PDF [1356 KB, uploaded 19 June 2014]
Abstract: Genetic and epigenetic information in eukaryotic cells is carried on chromosomes, basically consisting of large compact supercoiled chromatin fibers. Micromanipulations have recently led to great advances in the knowledge of the complex mechanisms underlying the regulation of DNA transaction events by nucleosome and chromatin structural changes. Indeed, magnetic and optical tweezers have allowed opportunities to handle single nucleosomal particles or nucleosomal arrays and measure their response to forces and torques, mimicking the molecular constraints imposed in vivo by various molecular motors acting on the DNA. These challenging technical approaches provide us with deeper understanding of the way chromatin dynamically packages our genome and participates in the regulation of cellular metabolism.
Keywords: DNA; nucleosome; chromatin; single molecule; magnetic tweezers; optical tweezers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |

MDPI and ACS Style

Lavelle, C.; Victor, J.-M.; Zlatanova, J. Chromatin Fiber Dynamics under Tension and Torsion. Int. J. Mol. Sci. 2010, 11, 1557-1579.

AMA Style

Lavelle C, Victor J-M, Zlatanova J. Chromatin Fiber Dynamics under Tension and Torsion. International Journal of Molecular Sciences. 2010; 11(4):1557-1579.

Chicago/Turabian Style

Lavelle, Christophe; Victor, Jean-Marc; Zlatanova, Jordanka. 2010. "Chromatin Fiber Dynamics under Tension and Torsion." Int. J. Mol. Sci. 11, no. 4: 1557-1579.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert