Next Article in Journal
Managing Phenol Contents in Crop Plants by Phytochemical Farming and Breeding—Visions and Constraints
Previous Article in Journal
Mutagenicity of New Lead Compounds to Treat Sickle Cell Disease Symptoms in a Salmonella/Microsome Assay
Previous Article in Special Issue
Review: Resin Composite Filling
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2010, 11(3), 789-806; doi:10.3390/ijms11030789

Interleukin 12 a Key Immunoregulatory Cytokine in Infection Applications

1
Biomaterials, Bioengineering & Nanotechnology Laboratory, Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, WV 26506, USA
2
Pharmaceutical and Pharmacological Sciences Graduate Program, Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA
3
Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506, USA
4
WVNano Initiative, Morgantown, WV 26506, USA
5
Department of Chemical Engineering, College of Engineering and Mineral Resources, West Virginia University, Morgantown, WV 26506, USA
*
Author to whom correspondence should be addressed.
Received: 9 January 2010 / Accepted: 24 February 2010 / Published: 26 February 2010
(This article belongs to the Special Issue Molecular Biomimetics and Materials Design)
View Full-Text   |   Download PDF [407 KB, uploaded 19 June 2014]   |  

Abstract

Interleukin 12 (termed IL-12p70 and commonly designated IL-12) is an important immunoregulatory cytokine that is produced mainly by antigen-presenting cells. The expression of IL-12 during infection regulates innate responses and determines the type of adaptive immune responses. IL-12 induces interferon-γ (IFN-γ) production and triggers CD4+ T cells to differentiate into type 1 T helper (Th1) cells. Studies have suggested that IL-12 could play a vital role in treating many diseases, such as viral and bacterial infections and cancers. The unique heterodimeric structure, which IL-12 shares with its family members including IL-23, IL-27, and IL-35, has recently brought more attention to understanding the mechanisms that regulate the functions of IL-12. This article describes the structure and biological activities of IL-12 in both the innate and adaptive arms of the immune system, and discusses the applications of IL-12 in treating and preventing infections.
Keywords: interleukin 12; infection; interferon-γ; cell-mediated immunity; cell signaling interleukin 12; infection; interferon-γ; cell-mediated immunity; cell signaling
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Hamza, T.; Barnett, J.B.; Li, B. Interleukin 12 a Key Immunoregulatory Cytokine in Infection Applications. Int. J. Mol. Sci. 2010, 11, 789-806.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top