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Int. J. Mol. Sci. 2010, 11(2), 521-531; doi:10.3390/ijms11020521
Article

Nuclear Translocation of Nuclear Factor Kappa B in First Trimester Deciduas and Chorionic Villi in Early Spontaneous Miscarriage Women

1
,
2,* , 3
 and
1
1 Xi’an Medical College, Xi’an, China 2 Center of Maternal and Child Health, First Affiliated Hospital of Medical School in Xi’an Jiaotong University, Xi’an, China 3 Department of Gynecology & Obstetrics, Fourth Hospital of Xi’an City, Xi’an, China
* Author to whom correspondence should be addressed.
Received: 24 December 2009 / Revised: 20 January 2010 / Accepted: 21 January 2010 / Published: 3 February 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The nuclear factor kappa B is widely expressed in the distinct subpopulations of chorionic villi and deciduas of first-trimester pregnancies. We examined the cellular distribution and expression of nuclear factor kappa B in the human first-trimester chorionic villi and deciduas of women with early spontaneous miscarriage and viable pregnancy by confocal laser scanning microscope and immunohistochemistry. There is a greater nuclear translocation of nuclear factor kappa B is restricted to villous stromal cells, decidual stromal cells, glandular epithelial cells and vessel endothelial cells in early spontaneous miscarriage than in viable pregnancies. Collectively these observations suggest that over-activation of nuclear factor kappa B has a relationship with early spontaneous miscarriages.
Keywords: early spontaneous miscarriage; nuclear factor kappa B; confocal laser scanning microscope; immunohistochemistry early spontaneous miscarriage; nuclear factor kappa B; confocal laser scanning microscope; immunohistochemistry
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Wang, L.-Q.; Yu, X.-W.; Yan, C.-F.; Wang, X. Nuclear Translocation of Nuclear Factor Kappa B in First Trimester Deciduas and Chorionic Villi in Early Spontaneous Miscarriage Women. Int. J. Mol. Sci. 2010, 11, 521-531.

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