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Int. J. Mol. Sci. 2010, 11(2), 521-531; doi:10.3390/ijms11020521
Article

Nuclear Translocation of Nuclear Factor Kappa B in First Trimester Deciduas and Chorionic Villi in Early Spontaneous Miscarriage Women

1
, 2,* , 3
 and 1
1 Xi’an Medical College, Xi’an, China 2 Center of Maternal and Child Health, First Affiliated Hospital of Medical School in Xi’an Jiaotong University, Xi’an, China 3 Department of Gynecology & Obstetrics, Fourth Hospital of Xi’an City, Xi’an, China
* Author to whom correspondence should be addressed.
Received: 24 December 2009 / Revised: 20 January 2010 / Accepted: 21 January 2010 / Published: 3 February 2010
(This article belongs to the Section Bioinorganic Chemistry)
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Abstract

The nuclear factor kappa B is widely expressed in the distinct subpopulations of chorionic villi and deciduas of first-trimester pregnancies. We examined the cellular distribution and expression of nuclear factor kappa B in the human first-trimester chorionic villi and deciduas of women with early spontaneous miscarriage and viable pregnancy by confocal laser scanning microscope and immunohistochemistry. There is a greater nuclear translocation of nuclear factor kappa B is restricted to villous stromal cells, decidual stromal cells, glandular epithelial cells and vessel endothelial cells in early spontaneous miscarriage than in viable pregnancies. Collectively these observations suggest that over-activation of nuclear factor kappa B has a relationship with early spontaneous miscarriages.
Keywords: early spontaneous miscarriage; nuclear factor kappa B; confocal laser scanning microscope; immunohistochemistry early spontaneous miscarriage; nuclear factor kappa B; confocal laser scanning microscope; immunohistochemistry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, L.-Q.; Yu, X.-W.; Yan, C.-F.; Wang, X. Nuclear Translocation of Nuclear Factor Kappa B in First Trimester Deciduas and Chorionic Villi in Early Spontaneous Miscarriage Women. Int. J. Mol. Sci. 2010, 11, 521-531.

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