Effect of Salvianolic Acid b and Paeonol on Blood Lipid Metabolism and Hemorrheology in Myocardial Ischemia Rabbits Induced by Pituitruin
Abstract
:1. Introduction
2. Materials and Method
2.1. Reagents
2.2. Animal Grouping and Treating
2.3. Biochemical Analysis of Serum
2.4. Statistical Analyses
3. Result
3.1. Effect of Compound of Salvianolic Acid b and Paeonol Treatment on Electrocardiogram T Wave of Rabbits
3.2. Effect of Compound of Salvianolic Acid b and Paeonol Treatment on Hemorrheology in Rabbits
3.3. Effect of Compound of Salvianolic Acid b and Paeonol Treatment on Blood MDA, NO, ET, NO/ET, LDH, and CPK
4. Discussion
5. Conclusion
Reference
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Group | n | 30 s | 1 min | 5 min | 10 min | 30 min |
---|---|---|---|---|---|---|
Normal | 8 | 020 ± 0.02 | 0.24 ± 0.10 | 0.19 ± 0.15 | 0.19 ± 0.22 | 0.03 ± 0.02 |
Model 1 | 8 | 0.33 ± 0.05ÄÄ | 0.51 ± 0.16ÄÄ | 0.56 ± 0.10ÄÄ | 0.59 ± 0.20ÄÄ | 0.30 ± 0.14ÄÄ |
Model 2 | 8 | 0.31 ± 0.06ÄÄ | 0.42 ± 0.11ÄÄ | 0.42 ± 0.10ÄÄ | 0.39 ± 0.17ÄÄ | 0.21 ± 0.12ÄÄ |
CSAP (15 mg/kg BW) | 8 | 0.17 ± 0.11** | 0.28 ± 0.14** | 0.23 ± 0.11** | 0.19 ± 0.13** | 0.04 ± 0.04** |
CSAP (10 mg/kg BW) | 8 | 0.19 ± 0.21** | 0.32 ± 0.18** | 0.25 ± 0.22** | 0.20 ± 0.16** | 0.08 ± 0.05** |
CSAP (5 mg/kg BW) | 8 | 0.22 ± 0.18* | 0.48 ± 0.46ÄÄ | 0.30 ± 0.21* | 0.27 ± 0.22Ä** | 0.13 ± 0.16Ä** |
SAB (12.5 mg/kg BW) | 8 | 0.21 ± 0.09** | 0.38 ± 0.11** | 0.27 ± 0.12** | 0.22 ± 0.12** | 0.10 ± 0.05** |
Paeonol (2.5 mg/kg BW) | 8 | 0.22 ± 0.14** | 0.38 ± 0.13** | 0.26 ± 0.13** | 0.21 ± 0.12** | 0.09 ± 0.03** |
CSP (20 μg·kg−1) | 8 | 0.16 ± 0.14** | 0.24 ± 0.18** | 0.23 ± 0.31** | 0.27 ± 0.33** | 0.01 ± 0.04** |
Group | Whole-blood Viscosity (mpa·s) | Plasma Viscosity (mpa·s) | Hematocrit (%) | Fibrinogen (g/L) | |
---|---|---|---|---|---|
Low Shear Rate | High Shear Rate | ||||
Normal | 7.36 ± 1.09 | 3.36 ± 0.21 | 1.12 ± 0.04 | 42.56 ± 2.82 | 1.68 ± 1.22 |
Model 1 | 13.12 ± 2.26ÄÄ | 4.50 ± 0.41ÄÄ | 1.37 ± 0.15ÄÄ | 46.88 ± 3.78Ä | 3.81 ± 1.56Ä |
Model 2 | 10.34 ± 2.04ÄÄ | 3.91 ± 0.39ÄÄ | 1.23 ± 0.14ÄÄ | 44.94 ± 3.47Ä | 2.98 ± 1.48Ä |
CSAP (15 mg/kg BW) | 9.73 ± 0.45** | 3.97 ± 0.55** | 1.19 ± 0.07** | 40.12 ± 7.03** | 2.09 ± 0.63** |
CSAP (10 mg/kg BW) | 9.89 ± 0.98** | 4.03 ± 0.18** | 1.19 ± 0.05** | 41.08 ± 5.72** | 2.59 ± 0.55** |
CSAP (5 mg/kg BW) | 10.12 ± 1.21*ÄÄ | 4.15 ± 0.27* | 1.21 ± 0.09** | 45.37 ± 6.21 | 2.83 ± 1.06* |
SAB (12.5 mg/kg BW) | 10.01 ± 0.89** | 4.06 ± 0.61** | 1.20 ± 0.08** | 42.73 ± 8.11** | 2.68 ± 0.71** |
Paeonol (2.5 mg/kg BW) | 9.95 ± 0.69** | 3.99±0.42** | 1.19 ± 0.06** | 43.37 ± 8.09** | 2.72 ± 0.84* |
CSP (20 μg·kg−1) | 9.78 ± 0.53** | 3.92 ± 0.67** | 1.17 ± 0.06** | 41.09 ± 7.13* | 2.11 ± 0.66** |
Group | n | MDA (nmol·mL−1) | NO (μmol·mL−1) | ET (pg·mL−1) | NO/ET |
---|---|---|---|---|---|
Normal | 8 | 2.25 ± 0.42 | 54.82 ± 17.59 | 335.07 ± 48.21 | 0.16 ± 0.05 |
Model 1 | 8 | 3.18 ± 0.53ÄÄ | 122.93 ± 23.15ÄÄ | 385.77 ± 56.21 | 0.32 ± 0.05ÄÄ |
Model 2 | 8 | 2.62 ± 0.49Ä | 107.68 ± 20.12ÄÄ | 378.32 ± 49.87 | 0.29 ± 0.05ÄÄ |
CSAP (15 mg/kg BW) | 8 | 1.95 ± 0.23* | 62.68 ± 11.12** | 263.45 ± 26.31ÄÄ | 0.24 ± 0.05* |
CSAP (10 mg/kg BW) | 8 | 2.42 ± 0.48* | 81.08 ± 12.10ÄÄ** | 317.21 ± 68.12 | 0.26 ± 0.08* |
CSAP (5 mg/kg BW) | 8 | 2.75 ± 0.62Ä* | 104.23 ± 13.42ÄÄ* | 365.41 ± 75.24 | 0.29 ± 0.10 |
SAB (12.5 mg/kg BW) | 8 | 2.25 ± 0.21* | 88.53 ± 18.04ÄÄ** | 321.37 ± 59.51 | 0.27 ± 0.06* |
Paeonol (2.5 mg/kg BW) | 8 | 2.33 ± 0.32* | 83.08 ± 15.39ÄÄ** | 336.72 ± 72.48 | 0.26 ± 0.05* |
CSP (20 μg·kg−1) | 8 | 1.93 ± 0.41* | 60.45 ± 15.12** | 258.87 ± 65.12** | 0.24 ± 0.07* |
Group | n | LDH | CPK |
---|---|---|---|
Normal | 8 | 532 ± 125 | 737 ± 258 |
Model 1 | 8 | 779 ± 318Ä | 1862 ± 437ÄÄ |
Model 2 | 8 | 713 ± 285Ä | 1659 ± 401ÄÄ |
CSAP (15 mg/kg BW) | 8 | 564 ± 151* | 790 ± 593** |
CSAP (10 mg/kg BW) | 8 | 688 ± 171 | 1022 ± 469* |
CSAP (5 mg/kg BW) | 8 | 763 ± 140 | 1715 ± 586 |
SAB (12.5 mg/kg BW) | 8 | 698±173 | 1274±638* |
Paeonol (2.5 mg/kg BW) | 8 | 709±183 | 1308±516* |
CSP (20 μg·kg−1) | 8 | 551 ± 124 | 803 ± 498** |
Abbreviations
CSAP | compound of salvianolic acid b and paeonol |
MDA | malonaldehyde |
LDH | lactate dehydrogenase |
CPK | creatine phosphokinase |
CAP | Compound salvia pellet |
CHD | coronary heart disease |
ET | endothelin |
NO | nitric oxide |
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
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Yang, Q.; Wang, S.; Xie, Y.; Wang, J.; Li, H.; Zhou, X.; Liu, W. Effect of Salvianolic Acid b and Paeonol on Blood Lipid Metabolism and Hemorrheology in Myocardial Ischemia Rabbits Induced by Pituitruin. Int. J. Mol. Sci. 2010, 11, 3696-3704. https://doi.org/10.3390/ijms11103696
Yang Q, Wang S, Xie Y, Wang J, Li H, Zhou X, Liu W. Effect of Salvianolic Acid b and Paeonol on Blood Lipid Metabolism and Hemorrheology in Myocardial Ischemia Rabbits Induced by Pituitruin. International Journal of Molecular Sciences. 2010; 11(10):3696-3704. https://doi.org/10.3390/ijms11103696
Chicago/Turabian StyleYang, Qian, Siwang Wang, Yanhua Xie, Jianbo Wang, Hua Li, Xuanxuan Zhou, and Wenbo Liu. 2010. "Effect of Salvianolic Acid b and Paeonol on Blood Lipid Metabolism and Hemorrheology in Myocardial Ischemia Rabbits Induced by Pituitruin" International Journal of Molecular Sciences 11, no. 10: 3696-3704. https://doi.org/10.3390/ijms11103696