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Int. J. Mol. Sci. 2010, 11(10), 3696-3704; doi:10.3390/ijms11103696
Article

Effect of Salvianolic Acid b and Paeonol on Blood Lipid Metabolism and Hemorrheology in Myocardial Ischemia Rabbits Induced by Pituitruin

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1,* , 1
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1 Institute of Materia Medica, School of pharmacy; Fourth Military Medical University, Xi'an, Shaanxi, 7l0032, China 2 Department of Neurosurgery, XiJing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 7l0032, China
* Author to whom correspondence should be addressed.
Received: 24 August 2010 / Revised: 15 September 2010 / Accepted: 16 September 2010 / Published: 28 September 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The purpose of this study was to determine the therapeutic effect of salvianolic acid b and paeonol on coronary disease. The ischemia myocardial animal model is induced by administering pituitrin (20 μg·kg−1) intravenously via the abdominal vein. A combination of salvianolic acid b and paeonol (CSAP) (5, 10 and 15 mg/kg BW) was administrated to experimental rabbits. Biochemical indices were evaluated during six weeks of intervention. We found that the compound of salvianolic acid b and paeonol (5, 10 and 15 mg/kg BW) can markedly and dose-dependently reduce fibrinogen and malonaldehyde levels, increase the HDL level, improve blood viscosity and plasma viscosity in rabbits. In addition, the medicine can still reduce the ratio of NO/ET and the contents of lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) in a dose-dependent manner. This study demonstrates that compound of salvianolic acid b and paeonol (5, 10 and 15 mg/kg BW) can improve the blood hemorrheology, decrease oxidative injury and repair the function of blood vessel endothelium, and subsequently prevent the development of Coronary disease.
Keywords: coronary disease; hemorrheology; lipid peroxidation; salvianolic acid b coronary disease; hemorrheology; lipid peroxidation; salvianolic acid b
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yang, Q.; Wang, S.; Xie, Y.; Wang, J.; Li, H.; Zhou, X.; Liu, W. Effect of Salvianolic Acid b and Paeonol on Blood Lipid Metabolism and Hemorrheology in Myocardial Ischemia Rabbits Induced by Pituitruin. Int. J. Mol. Sci. 2010, 11, 3696-3704.

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