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• Wang, S
• Xie, Y
• Wang, J
• Li, H
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• Liu, W
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• Wang, S
• Xie, Y
• Wang, J
• Li, H
• Zhou, X
• Liu, W
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• Wang, S
• Xie, Y
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• Li, H
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Int. J. Mol. Sci. 2010, 11(10), 3696-3704; doi:10.3390/ijms11103696

Article

Effect of Salvianolic Acid b and Paeonol on Blood Lipid Metabolism and Hemorrheology in Myocardial Ischemia Rabbits Induced by Pituitruin

Qian Yang ¹ , Siwang Wang ^1,* , Yanhua Xie ¹ , Jianbo Wang ¹ , Hua Li ¹ , Xuanxuan Zhou ¹  and Wenbo Liu ²

¹ Institute of Materia Medica, School of pharmacy; Fourth Military Medical University, Xi'an, Shaanxi, 7l0032, China ² Department of Neurosurgery, XiJing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 7l0032, China

* Author to whom correspondence should be addressed.

Received: 24 August 2010; in revised form: 15 September 2010 / Accepted: 16 September 2010 / Published: 28 September 2010

(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)

Download PDF Full-Text [203 KB, uploaded 28 September 2010 16:07 CEST]

Abstract: The purpose of this study was to determine the therapeutic effect of salvianolic acid b and paeonol on coronary disease. The ischemia myocardial animal model is induced by administering pituitrin (20 μg·kg⁻¹) intravenously via the abdominal vein. A combination of salvianolic acid b and paeonol (CSAP) (5, 10 and 15 mg/kg BW) was administrated to experimental rabbits. Biochemical indices were evaluated during six weeks of intervention. We found that the compound of salvianolic acid b and paeonol (5, 10 and 15 mg/kg BW) can markedly and dose-dependently reduce fibrinogen and malonaldehyde levels, increase the HDL level, improve blood viscosity and plasma viscosity in rabbits. In addition, the medicine can still reduce the ratio of NO/ET and the contents of lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) in a dose-dependent manner. This study demonstrates that compound of salvianolic acid b and paeonol (5, 10 and 15 mg/kg BW) can improve the blood hemorrheology, decrease oxidative injury and repair the function of blood vessel endothelium, and subsequently prevent the development of Coronary disease.

Keywords: coronary disease; hemorrheology; lipid peroxidation; salvianolic acid b

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