Next Article in Journal
Chemical Interactions and Their Role in the Microphase Separation of Block Copolymer Thin Films
Previous Article in Journal
Molecular System Bioenergetics—New Aspects of Metabolic Research
Int. J. Mol. Sci. 2009, 10(8), 3658-3670; doi:10.3390/ijms10083658

Co-Expression of Neighboring Genes in the Zebrafish (Danio rerio) Genome

Received: 14 July 2009 / Revised: 11 August 2009 / Accepted: 20 August 2009 / Published: 21 August 2009
View Full-Text   |   Download PDF [130 KB, uploaded 19 June 2014]   |   Browse Figures


Neighboring genes in the eukaryotic genome have a tendency to express concurrently, and the proximity of two adjacent genes is often considered a possible explanation for their co-expression behavior. However, the actual contribution of the physical distance between two genes to their co-expression behavior has yet to be defined. To further investigate this issue, we studied the co-expression of neighboring genes in zebrafish, which has a compact genome and has experienced a whole genome duplication event. Our analysis shows that the proportion of highly co-expressed neighboring pairs (Pearson’s correlation coefficient R>0.7) is low (0.24% ~ 0.67%); however, it is still significantly higher than that of random pairs. In particular, the statistical result implies that the co-expression tendency of neighboring pairs is negatively correlated with their physical distance. Our findings therefore suggest that physical distance may play an important role in the co-expression of neighboring genes. Possible mechanisms related to the neighboring genes’ co-expression are also discussed.
Keywords: gene expression; co-expression; neighboring genes; promoter; zebrafish gene expression; co-expression; neighboring genes; promoter; zebrafish
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Tsai, H.-K.; Huang, P.-Y.; Kao, C.-Y.; Wang, D. Co-Expression of Neighboring Genes in the Zebrafish (Danio rerio) Genome. Int. J. Mol. Sci. 2009, 10, 3658-3670.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert