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Int. J. Mol. Sci. 2009, 10(5), 2383-2411; doi:10.3390/ijms10052383
Article

To What Extent Is Water Responsible for the Maintenance of the Life for Warm-Blooded Organisms?

1,*  and 2
Received: 28 March 2009; in revised form: 4 May 2009 / Accepted: 13 May 2009 / Published: 22 May 2009
(This article belongs to the Special Issue Origin of Life)
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Abstract: In this work, attention is mainly focused on those properties of water which are essentially changed in the physiological temperature range of warm-blooded organisms. Studying in detail the half-width of the diffusion peak in the quasi-elastic incoherent neutron scattering, the behavior of the entropy and the kinematic shear viscosity, it is shown that the character of the translational and rotational thermal motions in water radically change near TH ~ 315 K, which can be interpreted as the temperature of the smeared dynamic phase transition. These results for bulk pure water are completed by the analysis of the isothermic compressibility and the NMR-spectra for water-glycerol solutions. It was noted that the non-monotone temperature dependence of the isothermic compressibility (βT) takes also place for the water-glycerol solutions until the concentration of glycerol does not exceed 30 mol%. At that, the minimum of βT shifts at left when the concentration increases. All these facts give us some reasons to assume that the properties of the intracellular and extracellularfluidsare close to ones for pure water. Namely therefore, we suppose that the upper temperature limit for the life of warm-blooded organisms [TD = (315 ± 3) K] is tightly connected with the temperature of the dynamic phase transition in water. This supposition is equivalent to the assertion that the denaturation of proteins at TTH is mainly provoked by the rebuilding of the H-bond network in the intracellular and extracellular fluids, which takes place at TTH. A question why the heavy water cannot be a matrix for the intracellular and extracellular fluids is considered. The lower physiological pH limit for the life of warm-blooded organisms is discussed.
Keywords: intracellular and extracellular fluids; upper physiological temperature limit; lower physiological pH limit; H-bond network; warm-blooded organisms; translational and rotational thermal motions; entropy; kinematic shear viscosity; normal and heavy water; smeared dynamic phase transition; water-glycerol solutions; isothermic compressibility; cancer tissues; blood; denaturation of proteins; ions; electrolyte solutions; birds intracellular and extracellular fluids; upper physiological temperature limit; lower physiological pH limit; H-bond network; warm-blooded organisms; translational and rotational thermal motions; entropy; kinematic shear viscosity; normal and heavy water; smeared dynamic phase transition; water-glycerol solutions; isothermic compressibility; cancer tissues; blood; denaturation of proteins; ions; electrolyte solutions; birds
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fisenko, A.I.; Malomuzh, N.P. To What Extent Is Water Responsible for the Maintenance of the Life for Warm-Blooded Organisms? Int. J. Mol. Sci. 2009, 10, 2383-2411.

AMA Style

Fisenko AI, Malomuzh NP. To What Extent Is Water Responsible for the Maintenance of the Life for Warm-Blooded Organisms? International Journal of Molecular Sciences. 2009; 10(5):2383-2411.

Chicago/Turabian Style

Fisenko, Anatoliy I.; Malomuzh, Nikolay P. 2009. "To What Extent Is Water Responsible for the Maintenance of the Life for Warm-Blooded Organisms?" Int. J. Mol. Sci. 10, no. 5: 2383-2411.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert