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Int. J. Mol. Sci. 2009, 10(5), 2031-2040; doi:10.3390/ijms10052031

Effects of Hydroxylpropyl-β-Cyclodextrin on in Vitro Insulin Stability

, , ,  and *
Jiangsu Key Laboratory for Supramolecular Medicinal and Applications, Nanjing Normal University, Nanjing 210097, P.R. China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 26 March 2009 / Revised: 15 April 2009 / Accepted: 17 April 2009 / Published: 6 May 2009
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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The objective of this study was to elucidate the effects of hydroxylpropyl-β-cyclodextrin (HP-β-CD) on the in vitro stability of insulin. It was found that HP-β-CD had positive effects on the stability of insulin in acid and base and under high temperature conditions. Furthermore, use of HP-β-CD could also increase the stability of disulfide bonds which are important to the conformation of insulin. Through 1H-NMR experiments it was found that the protective effect of HP-β-CD was due to complexation with insulin. The results suggest that the presence of HP-β-CD could improve the stability of insulin in different environments.
Keywords: Protection; insulin; stability; cyclodextrin Protection; insulin; stability; cyclodextrin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, L.; Zhu, W.; Song, L.; Wang, Y.; Jiang, H.; Xian, S.; Ren, Y. Effects of Hydroxylpropyl-β-Cyclodextrin on in Vitro Insulin Stability. Int. J. Mol. Sci. 2009, 10, 2031-2040.

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