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Int. J. Mol. Sci. 2009, 10(5), 2031-2040; doi:10.3390/ijms10052031

Effects of Hydroxylpropyl-β-Cyclodextrin on in Vitro Insulin Stability

, , ,  and *
Jiangsu Key Laboratory for Supramolecular Medicinal and Applications, Nanjing Normal University, Nanjing 210097, P.R. China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 26 March 2009 / Revised: 15 April 2009 / Accepted: 17 April 2009 / Published: 6 May 2009
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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The objective of this study was to elucidate the effects of hydroxylpropyl-β-cyclodextrin (HP-β-CD) on the in vitro stability of insulin. It was found that HP-β-CD had positive effects on the stability of insulin in acid and base and under high temperature conditions. Furthermore, use of HP-β-CD could also increase the stability of disulfide bonds which are important to the conformation of insulin. Through 1H-NMR experiments it was found that the protective effect of HP-β-CD was due to complexation with insulin. The results suggest that the presence of HP-β-CD could improve the stability of insulin in different environments.
Keywords: Protection; insulin; stability; cyclodextrin Protection; insulin; stability; cyclodextrin
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, L.; Zhu, W.; Song, L.; Wang, Y.; Jiang, H.; Xian, S.; Ren, Y. Effects of Hydroxylpropyl-β-Cyclodextrin on in Vitro Insulin Stability. Int. J. Mol. Sci. 2009, 10, 2031-2040.

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