Next Article in Journal
QSAR Analysis of 2-Amino or 2-Methyl-1-Substituted Benzimidazoles Against Pseudomonas aeruginosa
Next Article in Special Issue
Bidirectionality and Compartmentation of Metabolic Fluxes Are Revealed in the Dynamics of Isotopomer Networks
Previous Article in Journal
The Interplay between QSAR/QSPR Studiesand Partial Order Ranking and Formal Concept Analyses
Previous Article in Special Issue
Control and Regulation of Integrated Mitochondrial Function in Metabolic and Transport Networks
Int. J. Mol. Sci. 2009, 10(4), 1658-1669; doi:10.3390/ijms10041658
Communication

Origins of Systems Biology in William Harvey’s Masterpiece on the Movement of the Heart and the Blood in Animals

1,*  and 2
Received: 20 March 2009 / Revised: 13 April 2009 / Accepted: 14 April 2009 / Published: 17 April 2009
(This article belongs to the Special Issue Molecular System Bioenergetics)
View Full-Text   |   Download PDF [225 KB, uploaded 19 June 2014]   |   Browse Figures

Abstract

In this article we continue our exploration of the historical roots of systems biology by considering the work of William Harvey. Central arguments in his work on the movement of the heart and the circulation of the blood can be shown to presage the concepts and methods of integrative systems biology. These include: (a) the analysis of the level of biological organization at which a function (e.g. cardiac rhythm) can be said to occur; (b) the use of quantitative mathematical modelling to generate testable hypotheses and deduce a fundamental physiological principle (the circulation of the blood) and (c) the iterative submission of his predictions to an experimental test. This article is the result of a tri-lingual study: as Harvey’s masterpiece was published in Latin in 1628, we have checked the original edition and compared it with and between the English and French translations, some of which are given as notes to inform the reader of differences in interpretation.
Keywords: William Harvey; heart rhythm; circulation of the blood; mathematical deduction: experimental verification; systems biology William Harvey; heart rhythm; circulation of the blood; mathematical deduction: experimental verification; systems biology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Auffray, C.; Noble, D. Origins of Systems Biology in William Harvey’s Masterpiece on the Movement of the Heart and the Blood in Animals. Int. J. Mol. Sci. 2009, 10, 1658-1669.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert