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Int. J. Mol. Sci. 2009, 10(3), 880-888; doi:10.3390/ijms10030880
Article

Hypoglycemic Effects of Crude Polysaccharide from Purslane

1,* , 2
, 2
, 1, 1 and 2
1 Department of Food Science, XiChang College, Sichuan Province, 615000, P.R. China 2 Department of Bioengineering, Jilin Agricultural Science and Technology College, Jilin Province, 132101, P.R. China
* Author to whom correspondence should be addressed.
Received: 1 February 2009 / Revised: 19 February 2009 / Accepted: 23 February 2009 / Published: 2 March 2009
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The effects of crude polysaccharide from Purslane (CPP) on body weight (bw), blood glucose, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), triglyceride (TG) and serum insulin levels were studied in diabetes mellitus mice. CPP treatment (200, 400 mg/kg bw) for 28 days resulted in a significant decrease in the concentrations of fasting blood glucose (FBG), TC and TG. Furthermore, CPP significantly increased the concentration of HDL-c, body weight and serum insulin level in the mice. In addition, according to acute toxicity studies and single cell gel electrophoresis analysis, CPP did not produce any physical or behavioral signs of toxicity. More significantly, our data demonstrated CPP exhibited the best effects at the dose of 400 mg/kg bw. The above results suggest that CPP can control blood glucose and modulate the metabolism of glucose and blood lipids in diabetes mellitus mice, so we conclude that CPP should be evaluated as a candidate for future studies on diabetes mellitus.
Keywords: Diabetes; Purslane; polysaccharide; hypoglycemia Diabetes; Purslane; polysaccharide; hypoglycemia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Gong, F.; Li, F.; Zhang, L.; Li, J.; Zhang, Z.; Wang, G. Hypoglycemic Effects of Crude Polysaccharide from Purslane. Int. J. Mol. Sci. 2009, 10, 880-888.

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