Next Article in Journal / Special Issue
Participation of Low Molecular Weight Electron Carriers in Oxidative Protein Folding
Previous Article in Journal
In Vitro Models in Biocompatibility Assessment for Biomedical-Grade Chitosan Derivatives in Wound Management
Previous Article in Special Issue
Folding of Trp-cage Mini Protein Using Temperature and Biasing Potential Replica—Exchange Molecular Dynamics Simulations
Int. J. Mol. Sci. 2009, 10(3), 1314-1345; doi:10.3390/ijms10031314

Mechanism of Suppression of Protein Aggregation by α-Crystallin

1,* , 2 and 1
1 Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky pr. 33, 119071, Moscow, Russia 2 Oil and Gas Research Institute, Russian Academy of Sciences, Gubkina st. 3, 117971, Moscow, Russia
* Author to whom correspondence should be addressed.
Received: 30 January 2009 / Revised: 13 March 2009 / Accepted: 18 March 2009 / Published: 19 March 2009
(This article belongs to the Special Issue Protein Folding 2009)


This review summarizes experimental data illuminating the mechanism of suppression of heat-induced protein aggregation by a-crystallin, one of the small heat shock proteins. The dynamic light scattering data show that the initial stage of thermal aggregation of proteins is the formation of the initial aggregates involving hundreds of molecules of the denatured protein. Further sticking of the starting aggregates proceeds in a regime of diffusion-limited cluster-cluster aggregation. The protective effect of a-crystallin is due to transition of the aggregation process to the regime of reaction-limited cluster-cluster aggregation, wherein the sticking probability for the colliding particles becomes lower than unity.
Keywords: Chaperones; protein aggregation; α-crystallin Chaperones; protein aggregation; α-crystallin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Markossian, K.A.; Yudin, I.K.; Kurganov, B.I. Mechanism of Suppression of Protein Aggregation by α-Crystallin. Int. J. Mol. Sci. 2009, 10, 1314-1345.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert