Next Article in Journal / Special Issue
Protein Dynamics: From Molecules, to Interactions, to Biology
Previous Article in Journal / Special Issue
Mechanism of Suppression of Protein Aggregation by α-Crystallin
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2009, 10(3), 1346-1359; doi:10.3390/ijms10031346

Participation of Low Molecular Weight Electron Carriers in Oxidative Protein Folding

Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University & MTA-SE Pathobiochemistry Research Group, 1444 Budapest, POB 260, Hungary
*
Author to whom correspondence should be addressed.
Received: 3 February 2009 / Revised: 8 March 2009 / Accepted: 17 March 2009 / Published: 20 March 2009
(This article belongs to the Special Issue Protein Folding 2009)
View Full-Text   |   Download PDF [249 KB, uploaded 19 June 2014]   |  

Abstract

Oxidative protein folding is mediated by a proteinaceous electron relay system, in which the concerted action of protein disulfide isomerase and Ero1 delivers the electrons from thiol groups to the final acceptor. Oxygen appears to be the final oxidant in aerobic living organisms, although the existence of alternative electron acceptors, e.g. fumarate or nitrate, cannot be excluded. Whilst the protein components of the system are well-known, less attention has been turned to the role of low molecular weight electron carriers in the process. The function of ascorbate, tocopherol and vitamin K has been raised recently. In vitro and in vivo evidence suggests that these redox-active compounds can contribute to the functioning of oxidative folding. This review focuses on the participation of small molecular weight redox compounds in oxidative protein folding. View Full-Text
Keywords: Oxidative folding; ascorbate; tocopherol; vitamin K; protein disulfide isomerase; Ero1; endoplasmic reticulum; glutathione; small-molecule catalysts Oxidative folding; ascorbate; tocopherol; vitamin K; protein disulfide isomerase; Ero1; endoplasmic reticulum; glutathione; small-molecule catalysts
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Margittai, É.; Csala, M.; Mandl, J.; Bánhegyi, G. Participation of Low Molecular Weight Electron Carriers in Oxidative Protein Folding. Int. J. Mol. Sci. 2009, 10, 1346-1359.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top