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Molecules 2004, 9(7), 574-582; doi:10.3390/90700574

A Novel Synthesis of Arylpyrrolo[1,2-a]pyrazinone Derivatives

* ,  and
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China
* Author to whom correspondence should be addressed.
Received: 8 March 2004 / Accepted: 7 April 2004 / Published: 30 June 2004
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Some aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinones were designed and prepared to study the Structure-Activity Relationships (SAR) of pyrrolo[1,2-a]pyrazinone derivatives. With methyl pyrrole-2-carboxylate as the starting material, the title compounds were prepared through N-alkylation and two novel cyclizations. Eleven aryl-2-methyl-1- pyrrolo[1,2-a]pyrazinone derivatives not previously reported in the literature are presented in this paper. Some of them show potent anti-inflammatory and analgesic activities.
Keywords: Aryl-2-methyl-1-pyrrolo[1; 2-a]pyrazinones; synthesis; anti-inflammation. Aryl-2-methyl-1-pyrrolo[1; 2-a]pyrazinones; synthesis; anti-inflammation.
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Wang, F.; Wang, J.; Zhang, S. A Novel Synthesis of Arylpyrrolo[1,2-a]pyrazinone Derivatives. Molecules 2004, 9, 574-582.

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