A Novel Synthesis of Arylpyrrolo[1,2-a]pyrazinone Derivatives

doi:10.3390/90700574

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Molecules 2004, 9(7), 574-582; doi:10.3390/90700574

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A Novel Synthesis of Arylpyrrolo[1,2-a]pyrazinone Derivatives

Fei Wang* , Jiawei Wang and Shoufang Zhang

School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China

* Author to whom correspondence should be addressed.

Received: 8 March 2004 / Accepted: 7 April 2004 / Published: 30 June 2004

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Abstract: Some aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinones were designed and prepared to study the Structure-Activity Relationships (SAR) of pyrrolo[1,2-a]pyrazinone derivatives. With methyl pyrrole-2-carboxylate as the starting material, the title compounds were prepared through N-alkylation and two novel cyclizations. Eleven aryl-2-methyl-1- pyrrolo[1,2-a]pyrazinone derivatives not previously reported in the literature are presented in this paper. Some of them show potent anti-inflammatory and analgesic activities.

Keywords: Aryl-2-methyl-1-pyrrolo[1; 2-a]pyrazinones; synthesis; anti-inflammation.

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MDPI and ACS Style

Wang, F.; Wang, J.; Zhang, S. A Novel Synthesis of Arylpyrrolo[1,2-a]pyrazinone Derivatives. Molecules 2004, 9, 574-582.

AMA Style

Wang F, Wang J, Zhang S. A Novel Synthesis of Arylpyrrolo[1,2-a]pyrazinone Derivatives. Molecules. 2004; 9(7):574-582.

Chicago/Turabian Style

Wang, Fei; Wang, Jiawei; Zhang, Shoufang. 2004. "A Novel Synthesis of Arylpyrrolo[1,2-a]pyrazinone Derivatives." Molecules 9, no. 7: 574-582.

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