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Molecules 2004, 9(7), 574-582; doi:10.3390/90700574

A Novel Synthesis of Arylpyrrolo[1,2-a]pyrazinone Derivatives

* ,  and
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China
* Author to whom correspondence should be addressed.
Received: 8 March 2004 / Accepted: 7 April 2004 / Published: 30 June 2004
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Some aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinones were designed and prepared to study the Structure-Activity Relationships (SAR) of pyrrolo[1,2-a]pyrazinone derivatives. With methyl pyrrole-2-carboxylate as the starting material, the title compounds were prepared through N-alkylation and two novel cyclizations. Eleven aryl-2-methyl-1- pyrrolo[1,2-a]pyrazinone derivatives not previously reported in the literature are presented in this paper. Some of them show potent anti-inflammatory and analgesic activities.
Keywords: Aryl-2-methyl-1-pyrrolo[1; 2-a]pyrazinones; synthesis; anti-inflammation. Aryl-2-methyl-1-pyrrolo[1; 2-a]pyrazinones; synthesis; anti-inflammation.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, F.; Wang, J.; Zhang, S. A Novel Synthesis of Arylpyrrolo[1,2-a]pyrazinone Derivatives. Molecules 2004, 9, 574-582.

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