Masked ω-Lithio Ester Enolates: Synthetic Applications
AbstractThe protocol of lithiation by means of lithium and a catalytic (5% molar) amount of DTBB (4,4’-di-tert-butylbiphenyl), applied to ω-chloro ortho ester 6 under Barbier-type conditions gives, after final acid-catalyzed methanolysis, the corresponding functionalized esters 8 or 9 (for chlorotrimethylsilane as electrophile) or, after ortho ester deprotection and acid catalyzed treatment, the δ-lactones 11. The procedure is also practical for bicyclic ortho esters 14: the β-chloro OBO ester derivate generates the γ- lactones 15 and the γ-chloro OBO ester gives corresponding esters 8. View Full-Text
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Yus, M.; Torregrosa, R.; Pastor, I.M. Masked ω-Lithio Ester Enolates: Synthetic Applications. Molecules 2004, 9, 330-348.
Yus M, Torregrosa R, Pastor IM. Masked ω-Lithio Ester Enolates: Synthetic Applications. Molecules. 2004; 9(5):330-348.Chicago/Turabian Style
Yus, Miguel; Torregrosa, Rosario; Pastor, Isidro M. 2004. "Masked ω-Lithio Ester Enolates: Synthetic Applications." Molecules 9, no. 5: 330-348.