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Molecules 2004, 9(10), 867-875; doi:10.3390/91000867
Article

Reactivity of 2-Thiohydantoins Towards Various Electrophilic Reagents: Applications to the Synthesis of New 2-Ylidene-3,5-dihydro-4H-imidazol-4-ones.

1, 2 and 1,*
Received: 22 July 2004 / Accepted: 3 September 2004 / Published: 30 September 2004
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Abstract

A new route to 5-(imidazolidin-2-ylidene)-2-methylsulfanyl-3,5-dihydro-imidazol-4-ones 4a-c using ketene dithioacetal intermediates 3a-c is described. Thereactivity of thiohydantoin derivatives 2a-c towards N,N-dimethylformamide diethylacetal(DMF-DEA) was also explored using solvent-free technique under microwave irradiation(μω). The 1H- and 13C-NMR spectra of some representative products are discussed.
Keywords: Thiohydantoins; ketene dithioacetal; dimethylformamide diethylacetal; microwave irradiation. Thiohydantoins; ketene dithioacetal; dimethylformamide diethylacetal; microwave irradiation.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chérouvrier, J.-R.; Carreaux, F.; Bazureau, J.P. Reactivity of 2-Thiohydantoins Towards Various Electrophilic Reagents: Applications to the Synthesis of New 2-Ylidene-3,5-dihydro-4H-imidazol-4-ones.. Molecules 2004, 9, 867-875.

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