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Molecules 2003, 8(7), 556-564; doi:10.3390/80700556
Article

Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents

1, 1
 and
2,*
Received: 16 June 2003 / Revised: 25 June 2003 / Accepted: 25 June 2003 / Published: 15 July 2003
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Abstract

A new series of plasmepsin II (PM II) inhibitors has been prepared based on 4-aminopiperidine-tert-butyl-carbamate (1). These compounds might be useful as antimalarial drugs acting via a new mechanism, and therefore be less susceptible to parasite resistance now often observed with current antimalarial therapies. Some of the final compounds prepared exhibited encouraging inhibitory activity towards PM II.
Keywords: Malaria; Plasmepsin II; Reductive Amination; Suzuki Coupling Malaria; Plasmepsin II; Reductive Amination; Suzuki Coupling
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mueller, R.; Huerzeler, M.; Boss, C. Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents. Molecules 2003, 8, 556-564.

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