Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents

doi:10.3390/80700556

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Molecules 2003, 8(7), 556-564; doi:10.3390/80700556

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Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents

Reto Mueller¹, Marianne Huerzeler¹ and Christoph Boss^2,*

¹ University of Applied Sciences Basel, Gründenstrasse 40, CH-4132 Muttenz, Switzerland ² Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland

* Author to whom correspondence should be addressed.

Received: 16 June 2003; in revised form: 25 June 2003 / Accepted: 25 June 2003 / Published: 15 July 2003

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Abstract: A new series of plasmepsin II (PM II) inhibitors has been prepared based on 4-aminopiperidine-tert-butyl-carbamate (1). These compounds might be useful as antimalarial drugs acting via a new mechanism, and therefore be less susceptible to parasite resistance now often observed with current antimalarial therapies. Some of the final compounds prepared exhibited encouraging inhibitory activity towards PM II.

Keywords: Malaria; Plasmepsin II; Reductive Amination; Suzuki Coupling

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MDPI and ACS Style

Mueller, R.; Huerzeler, M.; Boss, C. Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents. Molecules 2003, 8, 556-564.

AMA Style

Mueller R, Huerzeler M, Boss C. Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents. Molecules. 2003; 8(7):556-564.

Chicago/Turabian Style

Mueller, Reto; Huerzeler, Marianne; Boss, Christoph. 2003. "Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents." Molecules 8, no. 7: 556-564.

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