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Molecules 2003, 8(7), 556-564; doi:10.3390/80700556

Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents

1, 1
1 University of Applied Sciences Basel, Gründenstrasse 40, CH-4132 Muttenz, Switzerland 2 Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland
* Author to whom correspondence should be addressed.
Received: 16 June 2003 / Revised: 25 June 2003 / Accepted: 25 June 2003 / Published: 15 July 2003
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A new series of plasmepsin II (PM II) inhibitors has been prepared based on 4-aminopiperidine-tert-butyl-carbamate (1). These compounds might be useful as antimalarial drugs acting via a new mechanism, and therefore be less susceptible to parasite resistance now often observed with current antimalarial therapies. Some of the final compounds prepared exhibited encouraging inhibitory activity towards PM II.
Keywords: Malaria; Plasmepsin II; Reductive Amination; Suzuki Coupling Malaria; Plasmepsin II; Reductive Amination; Suzuki Coupling
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Mueller, R.; Huerzeler, M.; Boss, C. Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents. Molecules 2003, 8, 556-564.

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