Next Article in Journal
A Carboxylic Acid from Ilex integra
Previous Article in Journal
Synthesis and Crystal Structure of Hexakis(imidazole) nickel (II) O,O′-diphenyldithiophosphate [Ni(Im)6](Ph2O2PS2)2
Molecules 2003, 8(12), 873-881; doi:10.3390/81200873
Article

Silane Reduction of 5-Hydroxy-6-methyl-pyridine-3,4-dicarboxylic Acid Diethyl Ester: Synthesis of Vitamin B6

 and *
DSM Nutritional Products§ R&D Chemical Process Technology, P.O. Box 3255, Bldg. 214/0.61, CH- 4002 Basel, Switzerland
* Author to whom correspondence should be addressed.
Received: 31 October 2003 / Revised: 1 December 2003 / Accepted: 10 December 2003 / Published: 31 December 2003
View Full-Text   |   Download PDF [49 KB, uploaded 18 June 2014]   |  

Abstract

Alternative methods for the synthesis of pyridoxine have been investigated. The key intermediate, 5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid diethyl ester (5), was reduced with either a silane monomer (MeSiH(OEt)2) or a polysiloxane (polymethylhydrosiloxane, PMHS) to afford crude pyridoxine. An isolation technique utilizing a commercially available resin was devised, affording the desired product, vitamin B6, in an overall yield of 38-54 % and a purity of 76%.
Keywords: Polymethylhydrosiloxane (PMHS); silanes; ester reduction; pyridoxine; vitamin B6 Polymethylhydrosiloxane (PMHS); silanes; ester reduction; pyridoxine; vitamin B6
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Dumond, Y.R.; Gum, A.G. Silane Reduction of 5-Hydroxy-6-methyl-pyridine-3,4-dicarboxylic Acid Diethyl Ester: Synthesis of Vitamin B6. Molecules 2003, 8, 873-881.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert