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Molecules 2003, 8(12), 873-881; doi:10.3390/81200873
Article

Silane Reduction of 5-Hydroxy-6-methyl-pyridine-3,4-dicarboxylic Acid Diethyl Ester: Synthesis of Vitamin B6

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DSM Nutritional Products§ R&D Chemical Process Technology, P.O. Box 3255, Bldg. 214/0.61, CH- 4002 Basel, Switzerland
* Author to whom correspondence should be addressed.
Received: 31 October 2003 / Revised: 1 December 2003 / Accepted: 10 December 2003 / Published: 31 December 2003
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Abstract

Alternative methods for the synthesis of pyridoxine have been investigated. The key intermediate, 5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid diethyl ester (5), was reduced with either a silane monomer (MeSiH(OEt)2) or a polysiloxane (polymethylhydrosiloxane, PMHS) to afford crude pyridoxine. An isolation technique utilizing a commercially available resin was devised, affording the desired product, vitamin B6, in an overall yield of 38-54 % and a purity of 76%.
Keywords: Polymethylhydrosiloxane (PMHS); silanes; ester reduction; pyridoxine; vitamin B6 Polymethylhydrosiloxane (PMHS); silanes; ester reduction; pyridoxine; vitamin B6
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Dumond, Y.R.; Gum, A.G. Silane Reduction of 5-Hydroxy-6-methyl-pyridine-3,4-dicarboxylic Acid Diethyl Ester: Synthesis of Vitamin B6. Molecules 2003, 8, 873-881.

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