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Molecules 2003, 8(12), 873-881; doi:10.3390/81200873
Article

Silane Reduction of 5-Hydroxy-6-methyl-pyridine-3,4-dicarboxylic Acid Diethyl Ester: Synthesis of Vitamin B6

 and *
Received: 31 October 2003 / Revised: 1 December 2003 / Accepted: 10 December 2003 / Published: 31 December 2003
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Abstract

Alternative methods for the synthesis of pyridoxine have been investigated. The key intermediate, 5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid diethyl ester (5), was reduced with either a silane monomer (MeSiH(OEt)2) or a polysiloxane (polymethylhydrosiloxane, PMHS) to afford crude pyridoxine. An isolation technique utilizing a commercially available resin was devised, affording the desired product, vitamin B6, in an overall yield of 38-54 % and a purity of 76%.
Keywords: Polymethylhydrosiloxane (PMHS); silanes; ester reduction; pyridoxine; vitamin B6 Polymethylhydrosiloxane (PMHS); silanes; ester reduction; pyridoxine; vitamin B6
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Dumond, Y.R.; Gum, A.G. Silane Reduction of 5-Hydroxy-6-methyl-pyridine-3,4-dicarboxylic Acid Diethyl Ester: Synthesis of Vitamin B6. Molecules 2003, 8, 873-881.

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