Molecules 2003, 8(12), 873-881; doi:10.3390/81200873
Article

Silane Reduction of 5-Hydroxy-6-methyl-pyridine-3,4-dicarboxylic Acid Diethyl Ester: Synthesis of Vitamin B6

Yves René Dumond and Andrew G. Gum* email
DSM Nutritional Products§ R&D Chemical Process Technology, P.O. Box 3255, Bldg. 214/0.61, CH- 4002 Basel, Switzerland
* Author to whom correspondence should be addressed.
Received: 31 October 2003; in revised form: 1 December 2003 / Accepted: 10 December 2003 / Published: 31 December 2003
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Abstract: Alternative methods for the synthesis of pyridoxine have been investigated. The key intermediate, 5-hydroxy-6-methyl-pyridine-3,4-dicarboxylic acid diethyl ester (5), was reduced with either a silane monomer (MeSiH(OEt)2) or a polysiloxane (polymethylhydrosiloxane, PMHS) to afford crude pyridoxine. An isolation technique utilizing a commercially available resin was devised, affording the desired product, vitamin B6, in an overall yield of 38-54 % and a purity of 76%.
Keywords: Polymethylhydrosiloxane (PMHS); silanes; ester reduction; pyridoxine; vitamin B6

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MDPI and ACS Style

Dumond, Y.R.; Gum, A.G. Silane Reduction of 5-Hydroxy-6-methyl-pyridine-3,4-dicarboxylic Acid Diethyl Ester: Synthesis of Vitamin B6. Molecules 2003, 8, 873-881.

AMA Style

Dumond YR, Gum AG. Silane Reduction of 5-Hydroxy-6-methyl-pyridine-3,4-dicarboxylic Acid Diethyl Ester: Synthesis of Vitamin B6. Molecules. 2003; 8(12):873-881.

Chicago/Turabian Style

Dumond, Yves R.; Gum, Andrew G. 2003. "Silane Reduction of 5-Hydroxy-6-methyl-pyridine-3,4-dicarboxylic Acid Diethyl Ester: Synthesis of Vitamin B6." Molecules 8, no. 12: 873-881.

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