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Molecules 2002, 7(3), 353-362; doi:10.3390/70300353
Article

Synthesis of 2,3-Dimethoxy-7-methyl-7,12-dihydro-6H-[1]-benzofuro-[2,3-c]-[1]-benzazepin-6,12-dione

*  and
Department of Chemistry, University of the West Indies, Mona, Kingston 7, Jamaica
* Author to whom correspondence should be addressed.
Published: 31 March 2002
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Abstract

Treatment of 5,6-dimethoxy-2-(methylphenylcarbamoyl)-benzofuran-3-carboxylic acid with PPA yielded 2,3-dimethoxy-7-methyl-7,12-dihydro-6H-[1]-benzofuro-[2,3-c]-[1]-benzazepin-6,12-dione. The analogous 2-[(5,6-dimethoxybenzofuran-2-carbonyl)methylamino]benzoic acid was resistant to cyclization, whereas 2-[(6-methoxybenzofuran-2-carbonyl)-amino]benzoic acid underwent cyclization to the corresponding 3,1-benzoxazin-4-one.
Keywords: PPA; cyclization; benzoxazinone; benzofuro-[2; 3-c]-[1]-benzazepin-6; 12-dione PPA; cyclization; benzoxazinone; benzofuro-[2; 3-c]-[1]-benzazepin-6; 12-dione
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Jackson, Y.A.; Marriott, K.-S.C. Synthesis of 2,3-Dimethoxy-7-methyl-7,12-dihydro-6H-[1]-benzofuro-[2,3-c]-[1]-benzazepin-6,12-dione. Molecules 2002, 7, 353-362.

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