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Molecules 2002, 7(3), 353-362; doi:10.3390/70300353

Synthesis of 2,3-Dimethoxy-7-methyl-7,12-dihydro-6H-[1]-benzofuro-[2,3-c]-[1]-benzazepin-6,12-dione

Department of Chemistry, University of the West Indies, Mona, Kingston 7, Jamaica
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Published: 31 March 2002
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Abstract

Treatment of 5,6-dimethoxy-2-(methylphenylcarbamoyl)-benzofuran-3-carboxylic acid with PPA yielded 2,3-dimethoxy-7-methyl-7,12-dihydro-6H-[1]-benzofuro-[2,3-c]-[1]-benzazepin-6,12-dione. The analogous 2-[(5,6-dimethoxybenzofuran-2-carbonyl)methylamino]benzoic acid was resistant to cyclization, whereas 2-[(6-methoxybenzofuran-2-carbonyl)-amino]benzoic acid underwent cyclization to the corresponding 3,1-benzoxazin-4-one.
Keywords: PPA; cyclization; benzoxazinone; benzofuro-[2; 3-c]-[1]-benzazepin-6; 12-dione PPA; cyclization; benzoxazinone; benzofuro-[2; 3-c]-[1]-benzazepin-6; 12-dione
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Jackson, Y.A.; Marriott, K.-S.C. Synthesis of 2,3-Dimethoxy-7-methyl-7,12-dihydro-6H-[1]-benzofuro-[2,3-c]-[1]-benzazepin-6,12-dione. Molecules 2002, 7, 353-362.

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