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Molecules 2001, 6(6), 519-527; doi:10.3390/60600519
Article

Heteroaromatization with 4-Hydroxycoumarin Part II: Synthesis of Some New Pyrano[2,3-d]pyrimidines, [1,2,4]triazolo[1,5-c]pyrimidines and Pyrimido[1,6-b]-[1,2,4]triazine Derivatives

1,* , 1, 2, 1 and 1
1 Department of Chemistry, Faculty of Science, Al- Azhar Univ. Nasr City, Cairo, Egypt 2 Department of Chemistry, Faculty of Science, Al- Azhar Univ. (Girls), Nasr City, Cairo, Egypt
* Author to whom correspondence should be addressed.
Received: 8 June 2000 / Revised: 16 September 2000 / Accepted: 15 February 2001 / Published: 31 May 2001
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Abstract

A variety of novel [1,2,4]triazolo[1,5-c]pyrimidine-13-ones (4a-f) and (5b-d) could be obtained via reaction of 9-amino-7-(4’-chlorophenyl)-8,9-dihydro-8-imino-6H,7H-[1]benzopyrano[3`,4`:5,6]pyrano[2,3-d]pyrimidine-6-one (3) with a variety of reagents. Pyrano[2,3-d]pyrimidine-6-ones 5a, 8a-c and pyrimido[1,6-b][1,2,4]-triazine-3,14-dione (6) were also prepared. The antimicrobial activity of some of the synthesized compounds was tested.
Keywords: Pyrano[3; 2-c][1]benzopyrans; Pyrano[2; 3-d]pyrimidines; [1; 2; 4]-triazolo- [1; 5-c]pyrimidines; Pyrimido[1; 6-b][1; 2; 4]triazine ; antimicrobial activities Pyrano[3; 2-c][1]benzopyrans; Pyrano[2; 3-d]pyrimidines; [1; 2; 4]-triazolo- [1; 5-c]pyrimidines; Pyrimido[1; 6-b][1; 2; 4]triazine; antimicrobial activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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El-Agrody, A.M.; Abd El-Latif, M.S.; El-Hady, N.A.; Fakery, A.H.; Bedair, A.H. Heteroaromatization with 4-Hydroxycoumarin Part II: Synthesis of Some New Pyrano[2,3-d]pyrimidines, [1,2,4]triazolo[1,5-c]pyrimidines and Pyrimido[1,6-b]-[1,2,4]triazine Derivatives. Molecules 2001, 6, 519-527.

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