Abstract: Several new pyrido[2,3,4-kl]acridines were synthesized by reacting naphthoquinone, juglone or cyclohexan-1,3-dione with β,β’-diaminoketones in a biomimetic reaction. The structure of all new compounds was elucidated by NMR and MS spectroscopy. Electrophilic substitution, mainly nitration, of the various compounds was undertaken and the substitution positions determined. A series of derivatives was prepared and their cytotoxicity towards P-388 mouse lymphoma cells analysed. The most cytotoxic derivatives were found to have IC50’s of 0.05 and 0.1 ug/ml.
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Koller, A.; Rudi, A.; Gravalos, M.G.; Kashman, Y. Synthesis and Electrophilic Substitution of Pyrido[2,3,4-kl]-acridines. Molecules 2001, 6, 300-322.
Koller A, Rudi A, Gravalos MG, Kashman Y. Synthesis and Electrophilic Substitution of Pyrido[2,3,4-kl]-acridines. Molecules. 2001; 6(4):300-322.
Koller, Avi; Rudi, Amira; Gravalos, Marta G.; Kashman, Yoel. 2001. "Synthesis and Electrophilic Substitution of Pyrido[2,3,4-kl]-acridines." Molecules 6, no. 4: 300-322.